Nerve conduction studies
| HNPP | Controls | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Nerve conduction measures | Correlation to aging | Mean (SD) | Correlation to aging | |||||||
| n | Mean (SD) | % of controls | p Values for controls* | r † | Regression slope | p Values for controls‡ | r † | Regression slope | ||
| *Mann-Whitney U test; †Pearson’s correlation coefficient; ‡regression slopes of HNPP and controls were compared. | ||||||||||
| Control values were obtained in 171 normal volunteers for the median nerve, 170 for the ulnar nerve, 161 for the tibial nerve, 171 for the peroneal nerve, and 163 for the sural nerve. | ||||||||||
| CMAP, compound muscle action potential; DL, distal latency; Duration, duration from the onset to the first crossing of the baseline in the CMAP and duration from the onset of the SNAP to the first negative peak; MCV, motor nerve conduction velocity; NS, not significant; SCV, sensory nerve conduction velocity; SNAP, sensory nerve action potential. | ||||||||||
| Motor conduction | ||||||||||
| Median nerve | ||||||||||
| MCV (m/s) | 47 | 46.0 (5.3) | 80 | <0.0001 | −0.25 | −0.073 | NS | 57.6 (3.8) | −0.27 | −0.064 |
| DL (ms) | 47 | 6.1 (1.8) | 179 | <0.0001 | 0.47 | 0.046 | <0.0001 | 3.4 (0.4) | 0.19 | 0.005 |
| CMAP (mV) | 48 | 6.3 (3.2) | 77 | <0.0001 | −0.67 | −0.122 | <0.01 | 8.2 (2.9) | −0.24 | −0.042 |
| Duration (ms) | 32 | 5.4 (0.8) | 115 | <0.001 | 0.13 | 0.006 | NS | 4.7 (0.9) | −0.07 | −0.004 |
| Ulnar nerve | ||||||||||
| MCV (m/s) | 47 | 46.9 (8.3) | 81 | <0.0001 | 0.04 | 0.018 | NS | 58.0 (4.6) | −0.22 | −0.062 |
| DL (ms) | 47 | 3.8 (0.8) | 146 | <0.0001 | 0.17 | 0.009 | NS | 2.6 (0.3) | 0.06 | 0.001 |
| CMAP (mV) | 48 | 6.0 (3.0) | 81 | <0.001 | −0.65 | −0.109 | <0.0001 | 7.4 (1.8) | −0.20 | −0.021 |
| Duration (ms) | 28 | 5.9 (1.2) | 116 | <0.0001 | −0.22 | −0.016 | NS | 5.1 (0.7) | −0.01 | −0.001 |
| Tibial nerve | ||||||||||
| MCV (m/s) | 45 | 39.6 (4.5) | 86 | <0.0001 | −0.02 | −0.006 | NS | 46.0 (3.8) | −0.34 | −0.079 |
| DL (ms) | 45 | 5.5 (1.3) | 138 | <0.0001 | 0.15 | 0.011 | NS | 4.0 (0.6) | 0.11 | 0.004 |
| CMAPs (mV) | 45 | 7.9 (3.7) | 67 | <0.0001 | −0.29 | −0.062 | NS | 11.8 (3.5) | −0.33 | −0.069 |
| Duration (ms) | 25 | 5.7 (1.3) | 114 | <0.01 | −0.18 | −0.012 | NS | 5.0 (0.7) | −0.17 | −0.008 |
| Peroneal nerve | ||||||||||
| MCV (m/s) | 38 | 35.7 (5.7) | 76 | <0.0001 | −0.11 | −0.042 | NS | 47.4 (4.5) | −0.38 | −0.101 |
| DL (ms) | 38 | 7.7 (2.3) | 167 | <0.0001 | −0.002 | −0.00004 | NS | 4.6 (1.1) | 0.04 | 0.002 |
| CMAP (mV) | 41 | 1.9 (1.8) | 56 | <0.0001 | −0.65 | −0.067 | <0.05 | 3.4 (2.0) | −0.22 | −0.027 |
| Duration (ms) | 16 | 6.4 (0.9) | 131 | <0.0001 | −0.09 | −0.006 | NS | 4.9 (0.9) | −0.17 | −0.009 |
| Sensory conduction | ||||||||||
| Median nerve | ||||||||||
| SCV (m/s) | 42 | 38.6 (10.1) | 69 | <0.0001 | −0.41 | −0.235 | <0.05 | 56.3 (5.3) | −0.26 | −0.085 |
| SNAP (μV) | 48 | 6.8 (6.2) | 24 | <0.0001 | −0.50 | −0.178 | NS | 28.0 (11.5) | −0.45 | −0.327 |
| Duration (ms) | 26 | 0.9 (0.4) | 150 | <0.0001 | 0.56 | 0.011 | <0.0001 | 0.6 (0.1) | −0.11 | −0.001 |
| Ulnar nerve | ||||||||||
| SCV (m/s) | 41 | 36.8 (8.4) | 68 | <0.0001 | −0.13 | −0.069 | NS | 54.5 (5.5) | −0.28 | −0.093 |
| SNAP (μV) | 48 | 6.6 (6.4) | 28 | <0.0001 | −0.45 | −0.170 | NS | 23.8 (10.3) | −0.37 | −0.240 |
| Duration (ms) | 26 | 0.9 (0.2) | 150 | <0.0001 | 0.08 | 0.001 | NS | 0.6 (0.1) | −0.05 | −0.00004 |
| Sural nerve | ||||||||||
| SCV (m/s) | 43 | 36.4 (6.9) | 74 | <0.0001 | −0.13 | −0.052 | NS | 49.2 (4.8) | −0.12 | −0.035 |
| SNAP (μV) | 48 | 7.1 (5.9) | 42 | <0.0001 | −0.37 | −0.124 | NS | 16.8 (7.8) | −0.38 | −0.177 |
| Duration (ms) | 21 | 0.9 (0.3) | 129 | <0.05 | 0.23 | 0.004 | NS | 0.7 (0.1) | 0.21 | 0.002 |