Biochemical and enzymatic investigations
| HVA, nmol/l(controls) | MHPG, nmol/l (controls) | 5-HIAA, nmol/l (controls) | Neopterin (FB),pmol/mg protein (controls) | Biopterin (FB),pmol/mg protein (controls) | GTP-CH (FB),µU/mg protein (controls) | |
|---|---|---|---|---|---|---|
| CSF levels of HVA (homovanillic acid), MHPG (3-methoxy-4-hydroxyphenylglycol), and 5-HIAA (5-hydroxyindolacetic acid). Fibroblast assays: Neopterin (FB): synthesis of neopterin in cytokine stimulated fibroblasts; Biopterin (FB): synthesis of biopterin in cytokine stimulated fibroblasts; GTP-CH (FB): GTP cyclohydrolase enzyme activity in fibroblasts. NA, not available. Control values for monoamines are age adjusted. | ||||||
| A.II-5 | 347 (87–372) | NA | 194 (58–190) | 24 (18–98) | 98 (154–303) | 0.83 (1.4–6.5) |
| A.II-7 | 99 (87–372) | 36 (29–64) | 67 (58–190) | 18 (18–98) | 50 (154–303) | 0.43 (1.4–6.5) |
| B.III-2 | 75 (87–372) | 28 (29–64) | 66 (58–190) | 10 (18–98) | 30 (154–303) | 0.39 (1.4–6.5) |
| C.IV-1 | 195 (330–668) | 29 (32–68) | 81 (109–214) | NA | NA | NA |