Demographic, clinical, and MRI parameters in patients (MS) and controls (NC) over the study course
| Baseline | Year 1 | Year 2 | Year 3 | p value for change over study | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MS | NC | MS | NC | MS | NC | MS | NC | MS | NC | |
| n = 27 | n = 20 | n = 25 | n = 20 | n = 25 | n = 17 | n = 24 | n = 12 | |||
| *The lower numbers are mean cord areas estimated from the longitudinal model in subjects with assigned mean TICV of their cohort at baseline. | ||||||||||
| Mean values unless stated; NA, not applicable. | ||||||||||
| Age (years) | 37.26 | 35.31 | 38.60 | 36.32 | 39.25 | 38.17 | 39.97 | 40.75 | NA | NA |
| Gender (male:female) | 8:19 | 10:10 | 7:18 | 10:10 | 7:18 | 10:7 | 7:17 | 10:2 | NA | NA |
| Median EDSS | 1.0 | NA | 1.5 | NA | 2.0 | NA | 2.0 | NA | 0.008 | NA |
| Brain PD lesion volume (ml) | 7.71 | 0 | 8.90 | 0 | 9.18 | 0 | 11.15 | 0 | 0.001 | NA |
| Brain T1 lesion volume (ml) | 1.72 | 0 | 1.76 | 0 | 1.89 | 0 | 2.59 | 0 | <0.001 | NA |
| Brain enhancing lesion volume (ml) | 0.64 | 0 | 0.56 | 0 | 0.26 | 0 | 0.32 | 0 | 0.179 | NA |
| Cord area* (mm2) | 78.91 | 80.50 | 77.90 | 81.37 | 77.12 | 81.07 | 76.25 | 83.88 | <0.001 | 0.215 |
| 79.02 | 79.77 | 78.21 | 80.12 | 77.39 | 80.47 | 76.58 | 80.82 | |||
| TICV (ml) | 1347.5 | 1358.1 | 1346.4 | 1368.8 | 1355.4 | 1364.6 | 1332.9 | 1340.8 | 0.791 | 0.817 |
| BPF | 0.812 | 0.835 | 0.804 | 0.832 | 0.802 | 0.831 | NA | NA | 0.011 | 0.123 |