| Subject | Phenotype of T cell line (%) | Per cent specific lysis of LCL | |||||
| Autologous LCL | HLA mismatched LCL | ||||||
| CD4+ | CD8+ | NK | E:T = 20:1 | E:T = 10:1 | E:T = 20:1 | E:T = 10:1 | |
| HC 4 | 7.7 | 86.9 | 0.9 | 46.5 | 37.4 | 13.4 | 8.1 |
| HC 12 | 16.1 | 85.3 | 1.1 | 40.2 | 36.2 | 6.3 | 6.0 |
| HC 14 | 59.4 | 31.7 | 0.6 | 36.8 | 27.1 | 10.1 | 6.5 |
| HC 24 | 29.5 | 67.2 | 2.8 | 54.3 | 49.4 | 19.1 | 15.1 |
| HC 31 | 23.4 | 71.9 | 3.8 | 52.4 | 43.1 | 9.1 | 7.6 |
| HC 32 | 47.8 | 45.2 | 0.7 | 49.0 | 40.9 | 6.1 | 5.5 |
| Mean HC | 30.6 (19.6) | 64.7 (22.1) | 1.0* | 46.5 (6.9) | 39.0 (7.5) | ||
| MS 192 | 60.9 | 38.8 | 1.0 | 17.0 | 7.1 | −1.7 | −5.1 |
| MS 210 | 20.3 | 73.2 | 3.5 | 69.2 | 63.3 | 12.1 | 9.1 |
| MS 211 | 45.3 | 54.8 | 0.5 | 39.3 | 29.5 | 2.3 | 3.7 |
| MS 212 | 7.6 | 90.0 | 1.7 | 45.5 | 30.1 | 9.0 | 5.4 |
| MS 215 | 40.5 | 60.1 | 1.1 | 46.3 | 35.4 | 5.4 | 2.1 |
| MS 428 | 19.0 | 63.3 | 8.7 | 95.1 | 96.2 | 15.9 | 14.9 |
| Mean MS | 32.3 (19.9) | 63.4 (17.3) | 1.4* | 52.1 (26.9) | 43.6 (31.4) | ||
| p Value† | 0.89 | 0.91 | 0.70‡ | 0.64 | 0.74 | ||
*Median.
†Student’s t test for comparison between Mean HC and Mean MS.
‡Mann–Whitney rank sum test for comparison of median per cent NK cells between HC and MS.
E:T, effector:target ratio; LCL, lymphoblastoid cell lines; Mean HC, mean (SD) in healthy control subjects; Mean MS, mean (SD) in patients with multiple sclerosis.