Effect of subthalamotomy on the cardinal features of Parkinson’s disease
| Cardinal sign | Preop | 12 months | 24 months | +36 months |
| “Off” motor state | ||||
| Rigidity (ipsilateral) | 4.6 (1.23) | 4.6 (1.23) | 4.8 (1.24) | 5.8 (1.50) |
| Rigidity (contralateral) | 6.1 (1.30) | 1.8 (1.04)** | 2.7 (1.00)** | 3.7 (1.53)** |
| Bradykinesia (ipsilateral) | 10.4 (2.66) | 9.0 (2.46) | 10.7 (2.98) | 12.4 (2.56) |
| Bradykinesia (contralateral) | 13.4 (2.32) | 4.6 (1.86)** | 6.1 (1.52)** | 8.1 (2.59)** |
| Tremor (ipsilateral) | 3.7 (2.55) | 3.4 (2.54) | 5.1 (2.53) | 5.7 (2.87) |
| Tremor (contralateral) | 5.5 (3.13) | 1.4 (1.41** | 2.4 (1.77)** | 3.3 (2.09)** |
| “On” motor state | ||||
| Rigidity (ipsilateral) | 1.9 (1.02) | 1.6 (0.94) | 2.0 (0.94) | 2.6 (1.22) |
| Rigidity (contralateral) | 2.9 ( 1.27) | 0.3 (0.72)** | 0.8 (0.84)** | 1.5 (1.19)** |
| Bradykinesia (ipsilateral) | 4.6 (1.79) | 3.6 (1.69) | 4.7 (1.93) | 5.5 (2.43) |
| Bradykinesia (contralateral) | 6.5 (2.00) | 1.1 (1.47)** | 2.0 (1.48)** | 3.6 (1.99)** |
| Tremor (ipsilateral) | 1.2 (1.33) | 1.0 (1.15) | 1.7 (1.47) | 2.3 (2.17)** |
| Tremor (contralateral) | 2.2 (1.98) | 0.2 (0.54)** | 0.5 (0.93)** | 1.0 (1.20)* |
Data presented as mean (SD).
*p<0.05, **p<0.01 between preoperative (Preop) compared with 12, 24 and +36 months postoperatively.