Comparison of chromosome 16 disease haplotypes from amyotrophic lateral sclerosis (ALS) families with FUS mutations
| Mutation R521H | Mutation R521C | |||||
| Marker | ALS2 | ALS156 | ALS31 | ALS53 | cM | Mb |
| D16S769 | X | 52.25 | 26.07 | |||
| D16S690 | 289 | X | X | X | 56.77 | 27.87 |
| D16S685 | 121 | 121 | 117 | 121 | 58.40 | 30.58 |
| FUS mutation | A | A | T | T | 31.11 | |
| D16S753 | 252 | 260 | 264 | 260 | 58.40 | 31.18 |
| D16S3044 | 198 | X | 198 | 190 | 59.06 | 46.00 |
| D16S541 | 154 | 150 | 150 | 63.37 | 49.15 | |
| D16S3034 | X | X | X | 67.57 | 51.70 | |
Haplotype alleles are in base pairs.
X denotes an observed recombination event between the indicated marker and the disease within a family. For each family, the minimal haplotype that segregates with disease is boxed.