Table 1

Relation of post-mortem measures of neurodegeneration to change in word knowledge*

	Word knowledge			Reading			Vocabulary
	Estimate	SE	p Value	Estimate	SE	p Value	Estimate	SE	p Value
Time	−0.011	0.012	0.363	0.097	0.046	0.033	−0.106	0.044	0.017
Alzheimer's disease pathology	0.025	0.073	0.740	0.375	0.358	0.295	−0.139	0.269	0.606
Time×Alzheimer's disease pathology	−0.082	0.012	<0.001	−0.366	0.050	<0.001	−0.262	0.045	<0.001
Time	−0.060	0.010	<0.001	−0.137	0.039	<0.001	−0.270	0.037	<0.001
Neocortical Lewy bodies	−0.038	0.139	0.782	−0.445	0.639	0.487	−0.119	0.505	0.814
Time×neocortical Lewy bodies	−0.125	0.024	<0.001	−0.283	0.101	0.005	−0.399	0.091	<0.001
Subcortical Lewy bodies	−0.065	0.134	0.625	0.174	0.618	0.778	−0.495	0.485	0.308
Time×subcortical Lewy bodies	−0.001	0.023	0.966	0.000	0.088	0.998	0.042	0.083	0.609
Time	−0.057	0.011	<0.001	−0.154	0.043	<0.001	−0.248	0.041	<0.001
Gross infarction	0.021	0.088	0.808	0.093	0.410	0.820	0.062	0.320	0.846
Time×gross infarction	−0.046	0.016	0.003	−0.039	0.062	0.528	−0.167	0.057	0.003
Time	−0.064	0.011	<0.001	−0.137	0.043	0.001	−0.274	0.041	<0.001
Microscopic infarction	−0.131	0.091	0.151	−0.448	0.421	0.288	−0.574	0.329	0.087
Time×microscopic infarction	−0.024	0.017	0.140	−0.100	0.064	0.119	−0.092	0.061	0.130

↵* From separate mixed-effects models adjusted for age at death, sex, education and their interactions with time.