Biochemical indices of bone metabolism before and after the 2-year period in the 250 subjects who completed the study
| Placebo-vitamin D group | Risedronate-vitamin D group | |||||
| Before n=136 | After n=124 | p* | Before n=136 | After n=126 | p* | |
| Hoehn and Yahr stages | 2.7±0.9 | 3.2±1.2 | <0.0001 | 2.7±1.3 | 3.1±1.3 | <0.0001 |
| Ionised calcium (mmol/l) | 1.31±0.04 | 1.33±0.05 | 0.001 | 1.30±0.05 | 1.25±0.03 | <0.0001 |
| Intact PTH (ng/l) | 33.2±11.9 | 25.1±108 | <0.0001 | 32.8±12.5 | 34.9±14.6 | 0.29 |
| Deoxypyridinoline (μmol/mol creatinine) | 12.0±4.2 | 14.3±4.0 | <0.0001 | 12.3±4.0 | 6.1±3.5 | <0.0001 |
| 25-OHD (nmol/l) | 29.8±10.5 | 85.0±12.7 | <0.0001 | 28.0±11.8 | 87.1±9.5 | <0.0001 |
| 1,25-[OH]2D (pmol/l) | 88.2±28.5 | 75.2±20.8 | <0.0001 | 85.6±31.5 | 89.4±28.1 | 0.30 |
Values are mean±SD.
↵* Paired t test.
PTH, parathyroid hormone; 25-OHD, 25-hydroxyvitamin D; 1,25-[OH]2D, 1,25-dihydroxyvitamin D.