Summary of clinical and neuropsychological characteristics
| fvFTLD (n=19) | tvFTLD (n=13) | Controls (n=22) | |
| Demographic data | |||
| Gender (M:F) | 15:4 | 6:7 | 11:11 |
| Handedness (R:L) | 17:2 | 12:1 | NA |
| Age (years) | 66.7 (8.7) | 63.5 (8.8) | 65.5 (8.5) |
| Behavioural data | |||
| MMSE | 27.3 (3.0) | 24.1 (3.7)‡ | NA |
| Benton face perception (/56) | 44.9 (7.0)† | 46.1 (4.4)† | 48.4 (2.6) |
| Famous Faces identification (/12) | 11.1 (1.5) | 7.9 (4.5)*‡ | NA |
| Ekman emotion recognition (/24) | 17.7 (4.8)† | 18.1 (3.4)† | 21.4 (1.9) |
| Individual emotions (% correct) | |||
| Anger | 60.5 (29.2) | 62.5 (23.5) | 89.5 (12.7) |
| Disgust | 73.7 (30.6) | 66.1 (31.9) | 96.1 (12.5) |
| Fear | 44.7 (34.9) | 62.5 (27.3) | 68.4 (27.4) |
| Happiness | 94.7 (13.4) | 91.1 (12.4) | 100.0 (0.0) |
| Sadness | 78.9 (28.0) | 83.9 (23.2) | 85.5 (20.9) |
| Surprise | 89.5 (24.0) | 85.7 (25.4) | 96.1 (9.4) |
| Object Decision Test (/20) | 17.2 (1.9) | 16.9 (3.1) | 17.5 (2.3) |
| Synonyms Test (/25) | 21.9 (3.3)† | 17.4 (6.1)†‡ | 26.1 (3.8) |
| Picture–word matching (/20) | 19.0 (1.6)† | 16.0 (3.5)†‡ | 19.8 (0.4) |
Mean (SD) values are shown.
↵* Five patients in this group fell below the 10th percentile score (7) based on normative data from an historical group of 100 healthy controls aged 55–70 years.
↵† Significantly worse (p<0.05) than controls.
↵‡ Significantly worse (p<0.05) than the fvFTLD group.
fvFTLD, frontal variant frontotemporal lobar degeneration; MMSE, Mini-Mental State Examination; NA, not available; tvFTLD, temporal variant frontotemporal lobar degeneration.