Table 5

Change from baseline in category rating scales for amount of symptoms and multiple sclerosis specific questionnaires

Variable		Cannabis extract (N=143)	Placebo (N=134)
Questionnaire	Section	Mean±SD	Mean±SD
CRS^*	Muscle stiffness	−1.8±2.6	−0.7±2.4^‡
	Body pain	−1.2±2.6	−0.3±2.4^‡
	Muscle spasms	−1.5±2.7	−0.7±2.4
	Quality of sleep	−1.4±3.1	−0.9±2.6
MSSS-88^§	Muscle stiffness	−5.0±8.5	−1.3±7.9^‡
	Pain and discomfort	−3.0±6.4	−1.6±6.2
	Muscle spasms	−5.2±9.9	−2.1±9.2^‡
	Effect of spasticity on activities of daily living	−1.3±8.0	−1.6±8.2
	Effect of spasticity on ability to walk	−3.0±5.7	−1.4±4.2
	Effect of spasticity on body movement	−3.9±7.7	−1.8±7.9^‡
	Effect of spasticity on feelings	−2.1±8.9	−1.8±9.1
	Effect of spasticity on social functioning	−1.2±6.2	−1.0±5.6
MSIS-29^§	Physical impact	−10.1±23.2	−4.2±18.5
MSIS-29^§	Psychological impact	−6.3±23.7	−3.8±22.8
MSWS-12^¶	Total score	−9.0±17.6	−1.7±12.4^‡

Scores were transformed to a 0–100 scale using the formula 100× (observed score−minimum score)/(maximum score−minimum score).
↵* Assessed by an 11 point numerical Likert scale (0=no symptom expression, …, 10=extreme symptom expression).
↵‡ Difference between cannabis extract and placebo: p<0.025 (one sided) (Lehmann's aligned rank test; factors for muscle stiffness and the MSSS-88—treatment, ambulatory status, spasticity medication; factors for body pain—treatment, analgesic medication, CRS baseline status; factors for muscle spasms and quality of sleep—treatment, spasticity medication, CRS baseline status; factors for MSIS-29—treatment, ambulatory status; factor for MSWS-12—treatment).
↵§ Possible answers: 1, not at all bothered/limited; 2, a little bothered/limited; 3, moderately bothered/limited; 4, extremely bothered/limited.
↵¶ Possible answers: 1, not at all; 2, a little; 3, moderately; 4, quite a bit; 5, extremely.
CRS, category rating scale; MSIS-29, Multiple Sclerosis Impact Scale; MSSS-88, Multiple Sclerosis Spasticity Scale; MSWS-12, Multiple Sclerosis Walking Scale; N, number of patients in specified treatment group; mean, mean change from baseline.