CAPIT UHDRS and motor assessments
| 0–2 years (2–4 years pre-T1) | 2–4 years (0–2 years pre-T0) | 4–6 years (0–2 years post-T0) | 6–8 years (2–4 years post-T0) | 8–10 years (4–6 years post-T0) | 10–12 years (6–8 years post-T0) | Groups | Time | Group×Time | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Tests | Years | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | Mean±SEM | F1,15 | F5,69 | F5,69 |
| UHDRS (total motor scale) | Control | 20.3±3.2 | 27.9±3.8 | 32.4±3.8 | 33.3±3.9 | 37.4±5.7 | 42.1±6.8 | 1.16 | 26.38** | 0.87 |
| Transplant | 26.3±7.2 | 39.0±9.7 | 38.7±11.1 | 44.2±12.3 | 35.8±5.4 | 46.0±7.9 | ||||
| UHDRS (functional assessment) | Control | 14.1±2.5 | 19.7±2.9 | 21.7±2.5 | 22.4±2.8 | 27.4±4.7 | 32.8±6.0 | 1.00 | 14.80** | 0.62 |
| Transplant | 19.5±5.0 | 28.0±8.1 | 27.3±10.4 | 31.6±12.8 | 22.7±5.9 | 35.3±9.1 | ||||
| UHDRS (ADL scale) | Control | 23.6±0.6 | 22.5±0.9 | 21.9±1.0 | 19.9±1.5 | 17.3±2.3 | 16.4±3.0 | 0.15 | 12.37** | 0.47 |
| Transplant | 23.2±0.9 | 22.3±1.0 | 22.1±0.8 | 18.0±3.1 | 18.4±2.2 | 14.3±3.5 | ||||
| UHDRS (independence scale) | Control | 92.4±2.9 | 86.6±3.2 | 83.2±3.0 | 77.8±3.1 | 72.5±4.7 | 66.6±6.1 | 0.23 | 26.14** | 0.43 |
| Transplant | 91.7±3.9 | 85.6±3.9 | 83.1±3.6 | 72.8±8.1 | 72.6±4.3 | 63.9±7.1 | ||||
| Fahn score | Control | 10.37±0.76 | 9.62±0.79 | 8.97±0.77 | 7.97±0.94 | 6.99±1.09 | 6.07±1.33 | 0.44 | 15.42** | 0.28 |
| Transplant | 9.68±0.98 | 8.42±1.34 | 8.78±0.90 | 7.18±1.41 | 6.08±1.43 | 5.13±2.19 | ||||
| Cognitive battery (total scores) | Control | 232±12 | 212±13 | 188±14 | 165±17 | 167±22 | 152±27 | 0.19 | 39.31** | 0.89 |
| Transplant | 220±22 | 217±29 | 186±28 | 152±32 | 159±32 | 125±40 | ||||
| Timed tests (walk) | Control | 9.76±0.56 | 9.81±0.30 | 11.20±0.67 | 11.93±0.64 | 13.28±0.50 | 17.30±2.84 | 4.05 | 9.90** | 2.67* |
| Transplant | 9.38±0.34 | 9.98±0.47 | 10.66±1.38 | 10.05±1.06 | 10.12±1.34 | 10.40±1.57 | ||||
| Timed tests (hand tap L&R) | Control | 86.8±7.2 | 79.4±5.4 | 67.8±5.5 | 60.4±4.7 | 52.7±4.5 | 48.4±5.3 | 0.08 | 36.27** | 0.79 |
| Transplant | 82.8±10.1 | 77.3±11.1 | 72.8±13.0 | 62.9±15.8 | 68.8±15.9 | 62.7±17.7 | ||||
| Timed tests (drink) | Control | 13.23±1.03 | 13.29±1.90 | 15.07±1.86 | 19.21±3.32 | 19.33±4.42 | 24.30±6.83 | 0.49 | 6.20** | 1.51 |
| Transplant | 5.00±* | 10.38±2.23 | 12.06±4.18 | 16.96±7.28 | 9.35±2.71 | 11.00±4.48 |
**p<0.001; *p<0.05 (not significant when correcting for multiple comparisons); transplant improved (+), or impaired (−) with respect to the reference controls.
UHDRS (total motor score): 0–124, 124 worse; UHDRS (functional assessment): 25–50, 50 worse; UHDRS (ADL scale): 0 worse; UHDRS (independence scale); 0–100, 0 worse,; Fahn score: 0–13, 0 worse; Cognitive battery: 0 worse; Timed tests (walk, hand tap (l & r) and drink): 0 worse.
CAPIT, Core assessment program for intracerebral transplantations; ADL, activities of daily living; UHDRS, Unified Huntington’s Disease Rating Scale.
Note: all significant results are identified in bold.