Patient characteristics
| n (%) | Overall (n=121) | Strictly lobar ICH (n=76) | Other ICH (n=45) | p Value |
|---|---|---|---|---|
| Age, mean (95% CI), years | 69.4 (67.2 to 69.6) | 71.1 (68.4 to 73.8) | 66.6 (62.8 to 72.4) | 0.05 |
| Sex, male | 69 (57) | 41 (54) | 28 (62.2) | 0.449 |
| History of hypertension | 86 (72.9) | 49 (67.1) | 37 (82.2) | 0.090 |
| Smoking history | 39 (33.3) | 22 (30.1) | 17 (38.6) | 0.419 |
| Diabetes | 20 (17.1) | 11 (15.1) | 9 (20.5) | 0.459 |
| On statins | 26 (22) | 15 (20.6) | 11 (25) | 0.648 |
| On antithrombotics | 38 (32.8) | 27 (37) | 11 (25.6) | 0.226 |
| First-ever ICH | 68 (63) | 40 (62.5) | 28 (63.6) | 1.000 |
| Lacunar infarct | 25 (49) | 11 (37.9) | 14 (63.6) | 0.093 |
| Multiple ICHs | 47 (39.8) | 34 (46.6) | 13 (28.9) | 0.081 |
| Microbleeds presence | 79 (67.5) | 45 (62.5) | 34 (75.6) | 0.160 |
| Microbleeds type | ||||
| Lobar | 77 (64.7) | 45 (62.5) | 30 (68.2) | 0.556 |
| Deep | 28 (23.1) | 0 | 28 (63.6) | <0.0001 |
| Mean total white matter changes score (95% CI) | 8.58 (7.59 to 9.57) | 8.21 (6.95 to 9.46) | 9.18 (7.53 to 10.83) | 0.346 |
| Mean total EPVS score (95% CI) | 4.38 (4.18 to 4.58) | 4.29 (4.04 to 4.54) | 4.53 (4.17 to 4.9) | 0.255 |
| Mean basal ganglia EPVS score (95% CI) | 1.50 (1.37 to 1.63) | 1.32 (1.18 to 1.45) | 1.8 (1.56 to 2.05) | 0.0003 |
| Mean centrum semiovale EPVS score (95% CI) | 2.85 (2.72 to 3.05) | 2.97 (2.76 to 3.19) | 2.73 (2.47 to 2.99) | 0.1590 |
| EPVS centrum semiovale | ||||
| Mild: 1–10 | 7 (5.8) | 4 (5.3) | 3 (6.7) | 0.338* |
| Moderate: 11–20 | 36 (29.8) | 21 (27.6) | 15 (33.3) | |
| Frequent: 21–40 | 43 (35.5) | 24 (31.6) | 18 (40) | |
| Severe: >40 | 35 (28.9) | 27 (35.5)† | 8 (17.8)† | |
| EPVS basal ganglia | ||||
| No EPVS | 2 (1.7) | 2 (2.6) | 0 (0) | 0.005* |
| Mild: 1–10 | 70 (57.9) | 51 (67.1) | 19 (42.2) | |
| Moderate: 11–20 | 37 (30.6) | 20 (26.3) | 17 (37.8) | |
| Frequent: 21–40 | 11 (9.1) | 3 (4) | 8 (17.8) | |
| Severe: >40 | 1 (0.8) | 0 (0) | 1 (2.2) | |
p Values refer to differences between strictly lobar (clinically probable or possible CAA) and other ICH.
*p Value for trend across groups.
†Statistically significant difference between strictly lobar (possible or probable CAA) and other ICH (see figure 2 for age-adjusted prevalences).
CAA, cerebral amyloid angiopathy; EPVS, enlarged perivascular spaces; ICH, intracerebral haemorrhage.