Primary progressive MS | Differential diagnosis |
---|---|
Degenerative | |
MND | Infective/Inflammatory |
Structural (c. spine/Chiari) | HIV |
Hereditary | Syphilis |
HSP—SCAs | Prions |
Leukodystrophies (AMN, Krabbe's), PKU | Vasculitis, sarcoid, lupus |
Metabolic | Schistosomiasis, Brucellosis |
Vitamins B12, E | Neoplastic (paraneoplasia) |
Copper | Idiopathic/cryptic |
Hypothyroidism | |
Toxic—phenytoin, lathyrism, nitric oxide | |
Alcohol |
AMN, adrenomyeloneuropathy; HSP, hereditary spastic paraplegia; MND, motor neuron disease; NO, nitric oxide; PKU, phenylketonuria; SCA, spinocerebellar ataxia.