Multivariable regression analyses for basal ganglia and centrum semiovale PVS severity
| OR (95% CI) | p Value | |
|---|---|---|
| Basal Ganglia PVS | ||
| Age (for every 5-year increase) | 1.18 (0.98 to 1.43) | 0.081 |
| Hypertension (yes vs no) | 4.89 (1.39 to 17.21) | 0.013 |
| Median WMH score | 1.27 (1.14 to 1.43) | <0.0001 |
| Lobar CMBs number | 0.82 (0.42 to 1.60) | 0.551 |
| Deep CMBs number | 1.77 (0.59 to 5.33) | 0.312 |
| Presence of lacunes | 2.93 (1.10 to 7.84) | 0.032 |
| Centrum Semiovale PVS | ||
| Age (for every 5-year increase) | 1.19 (1.04 to 1.37) | 0.013 |
| Hypertension (yes vs no) | 3.71 (1.42 to 9.59) | 0.007 |
| Median WMH score | 0.99 (0.89 to 1.10) | 0.840 |
| Lobar CMBs number | 1.34 (0.60 to 2.95) | 0.476 |
| Number of lacunes | 1.58 (0.45 to 5.57) | 0.478 |
All the variables listed in the table have been used in the each multivariable model to assess their independent effect on PVS severity in the respective anatomical location. The results remain consistent after adjusting for transient ischaemic attack diagnosis in the models.
Statistically significant results are in bold.
CI, confidence interval; OR, odds ratio; PVS, perivascular spaces; WMH, white matter hyperintensities.