Human fetal striatal transplantation effect on Unified Huntington's Disease (HD) Rating Scale (UHDRS) total scores
| Total HD patients’ series | Grafted HD patients’ series | |||||
|---|---|---|---|---|---|---|
| Slope (95% CI) | Δintercept (95% CI) | Δslope (95% CI) | Slope (95% CI) | Δintercept (95% CI) | Δslope (95% CI) | |
| Functional | −0.7 (−1.0 to −0.4) | −1.0 (−1.9 to −0.1) | 0.1 (−0.1 to 0.2) | −0.9 (−1.2 to −0.5) | −0.6 (−1.6 to 0.3) | 0.2 (0.0 to 0.4) |
| Behavioural | −1.1 (−2.2 to 0.01) | −1.0 (−4.5 to 2.6) | 0.2 (−0.5 to 0.9) | 0.3 (−1.2 to 1.8) | −3.3 (−7.0 to 0.4) | −0.5 (−1.3 to 0.2) |
| Cognitive | −11.5 (−16 to −7.3) | −2.0 (−14.4 to 10.3) | 2.7 (0.1 to 5.3) | −15.0 (−20.0 to −9.5) | 7.4 (−5.2 to 20.1) | 4.1 (1.8 to 6.5) |
| Motor | 5.2 (3.9 to 6.5) | −2.3 (−5.8 to 1.2) | −0.9 (−1.6 to −0.2) | 6.7 (5.1 to 8.3) | −6.8 (−10.6 to −3.0) | −2.0 (−2.8 to −1.2) |
Left panel: total HD patients’ series, right panel: grafted patients only.
UHDRS functional and cognitive score decrease indicates deterioration (better up), behavioural and motor score increase indicates deterioration (better down).
Columns 1 and 4: variation (‘slope’, in units/year) of total scores of the UHDRS over time since onset of symptoms.
Change-in-intercept (columns 2 and 5) and change-in-slope (columns 3 and 6): transplantation effect measures. Bold values if false discovery rate <0.10. Δintercept: average difference in total scores at time of transplantation. Δslope: difference in slope before/after transplantation.