FTM scale, item | Maximal possible score | Non-blinded DBS ‘off’ | Non-blinded DBS ‘on’ | Blinded DBS ‘off’ | Blinded DBS ‘on’ | p Value* | p Value† |
---|---|---|---|---|---|---|---|
Sum ETRS (1–14) | 116 | 58.62 | 34.08 | 56.07 | 35.23 | <0.001 | <0.001 |
Tremor scores (1–9) | 80 | 29.62 | 12.85 | 28.2 | 14.85 | 0.001 | 0.002 |
Voice tremor | 4 | 1.38 | 0.77 | 2.08 | 2.15 | 0.001 | 0.673 |
Head tremor‡ | 8 | 1.23 | 0.38 | 1.38 | 0.69 | 0.011 | 0.013 |
Tremor upper extremity§ | |||||||
Ipsilateral | 12 | 7.5 | 5.33 | 6.33 | 5.5 | 0.077 | 0.197 |
Contralateral | 12 | 8.7 | 3.55 | 8.7 | 4.0 | <0.001 | <0.001 |
RUE (item 5) | |||||||
Rest | 4 | 2.15 | 0.08 | 2.15 | 0.23 | <0.001 | 0.001 |
Postural | 4 | 2.77 | 0.92 | 2.85 | 1.15 | <0.001 | 0.002 |
Action | 4 | 2.77 | 1.54 | 2.77 | 1.62 | 0.001 | 0.002 |
Handwriting (item 10) | 4 | 2.69 | 1.46 | 2.23 | 1.31 | 0.002 | 0.002 |
Hand function (items 11–14) | |||||||
Ipsilateral | 16 | 11.67 | 11.0 | 10.67 | 9.83 | 0.102 | 0.102 |
Contralateral | 16 | 13.55 | 9.55 | 13.75 | 9.45 | <0.001 | 0.001 |
*Comparison between non-blinded DBS on/off.
†Comparison between blinded on/off DBS.
‡Includes rest and postural tremor.
§Includes, rest postural and action tremor. Contralateral hemibodies n=20, ipsilateral hemibodies n=6.
DBS, deep brain stimulation; ETRS, Essential Tremor Rating Scale; FTM, Fahn–Tolosa–Marin; RUE, right upper extremity.