Test characteristics of the MRI criteria include the 2007 and 2012 IPMSSG consensus definitions when applied to distinguish MS from other acquired demyelinating syndromes (ADS) of the CNS
| First MRI 2007 DIS | First MRI 2007 DIS | First MRI 2012 DIS | First MRI 2012 DIT | First MRI 2012 DIS+DIT | First and second MRI 2007 DIS+DIT | First and second MRI 2012 DIS+DIT | |
|---|---|---|---|---|---|---|---|
| McDonald 2001 criteria (at least three out of four) ▸ ≥9 lesions on T2-weighted images or one gadolinium-enhancing lesion ▸ ≥3 Periventricular lesions ▸ ≥1 Juxtacortical lesion ▸ ≥1 Infrantentorial lesion | ▸ Abnormal CSF ▸ Two lesions on the MRI of which one must be in the brain* | McDonald 2010 criteria (at least two out of four) ▸ ≥1 Spinal cord ▸ ≥1 Periventricular ▸ ≥1 Juxtacortical lesion ▸ ≥1 Infrantentorial lesion | McDonald 2010 criteria ▸ Simultaneous presence of asymptomatic gadolinium-enhancing and non-enhancing lesions ▸ Excluding children ≤12 years old† | McDonald 2010 for DIS and DIT at baseline ▸ Excluding children ≤12 years old† | McDonald 2001 DIT ▸ New T2- or gadolinium-enhancing lesion(s) more than 3 months after onset on follow-up MRI ▸ Excluding children ≤10 years old‡ | McDonald 2010 DIT ▸ New T2 and/or gadolinium-enhancing lesion(s) on follow-up MRI, with reference to a baseline scan irrespective of the timing of the baseline scan ▸ Simultaneous presence of asymptomatic gadolinium-enhancing and non-enhancing lesions at any time§ | |
| Sensitivity (%) | 70 | 75 | 93 | 63 | 58 | 68 | 79 |
| Specificity (%) | 96 | 89 | 77 | 100 | 100 | 100 | 100 |
| PPV (%) | 91 | 81 | 71 | 100 | 100 | 100 | 100 |
| NPV (%) | 83 | 85 | 95 | 82 | 80 | 71 | 88 |
| Accuracy (%) | 86 | 84 | 83 | 86 | 85 | 82 | 92 |
In this table, test characteristics are presented with CDMS as endpoint using first and second MRI.
*Calculated for patients when CSF was performed (n=73).
†Calculated for children who had a first MRI with gadolinium (n=65).
‡Calculated for children who had a second MRI following 3 months after onset (n=39).
§Calculated for children who had their first MRI with gadolinium and/or had second MRI, excluding children ≤12 years old for DIT 2010 at baseline (n=73).
CDMS, clinical definite multiple sclerosis; CNS, central nervous system; CSF, cerebrospinal fluid; DIS, dissemination in space; DIT, dissemination in time; IPMSSG, International Paediatric Multiple Sclerosis Study Group; MS, multiple sclerosis; NPV, negative predictive value; PPV, positive predictive value.