STN-DBS effects on PDQ-39 summary index (SI) and different subdomains
| Mean scores±SD (possible range) | Baseline (n=41) | Baseline of 8-year follow-up | 1 years post-op | 5 years post-op | 8 years post-op | p Value (5 years vs baseline) | p Value (8 years vs baseline) |
|---|---|---|---|---|---|---|---|
| PDQ-39 SI (0–100)* | 38.2±17.2 | 45.6±19.2 | 28.9±14.2 | 37.5±18.5 | 44.9±15.1 | 0.886 | 0.932 |
| Mobility | 50.9±24.9 | 55.9±29.8 | 35.8±27.6 | 42.4±29.0 | 51.8±28.9 | 0.414 | 0.713 |
| Activities daily living | 39.6±18.8 | 49.6±20.4 | 23.0±14.7 | 36.3±22.7 | 39.0±17.0 | 0.759 | 0.131 |
| Emotional | 21.8±14.9 | 23.1±15.6 | 18.0±18.2 | 22.3±20.2 | 23.9±16.0 | 0.961 | 0.866 |
| Stigma | 24.1±21.8 | 31.8±23.5 | 17.9±16.9 | 16.3±16.6 | 22.2±19.9 | 0.162 | 0.364 |
| Support | 12.7±13.7 | 15.9±12.0 | 8.0±11.0 | 14.5±19.7 | 14.4±21.8 | 0.711 | 0.837 |
| Cognition | 21.9±14.8 | 23.3±17.0 | 20.4±13.4 | 28.0±15.8 | 24.4±12.3 | 0.709 | 0.870 |
| Communication | 27.7±24.2 | 33.3±28.6 | 31.1±21.7 | 40.8±22.6 | 61.4±22.8 | 0.002 | 0.002 |
| Bodily discomfort | 46.2±26.2 | 54.6±27.7 | 28.3±20.8 | 33.0±21.9 | 47.7±21.8 | 0.013 | 0.520 |
*Higher scores indicate worse condition.
DBS, deep brain stimulation; STN, subthalamic nucleus.