Differences in muscle strength between sides according to disease severity as assessed with the CMT Neuropathy Score (CMTNS)
| CMTNS | N | Mean±SD | p Value for Δ* | |||
|---|---|---|---|---|---|---|
| D | ND | Δ | ||||
| FDI | Mild | 55 | 4.15±0.40 | 4.18±0.43 | −0.04±0.33 | 0.634 |
| Moderate | 187 | 3.80±0.72 | 3.82±0.82 | −0.02±0.39 | ||
| Severe | 25 | 2.24±1.20 | 2.20±1.22 | 0.04±0.35 | ||
| APB | Mild | 55 | 4.22±0.76 | 4.31±0.77 | −0.09±0.40 | 0.202 |
| Moderate | 187 | 3.83±0.89 | 3.84±0.87 | −0.01±0.37 | ||
| Severe | 26 | 2.77±1.27 | 2.77±1.42 | 0.00±0.57 | ||
| AT | Mild | 55 | 4.45±0.69 | 4.36±0.59 | 0.09±0.40 | 0.192 |
| Moderate | 187 | 3.32±1.27 | 3.31±1.32 | 0.01±0.64 | ||
| Severe | 25 | 1.76±1.33 | 1.68±1.38 | 0.08±0.49 | ||
| TS | Mild | 55 | 4.98±0.13 | 4.98±0.13 | 0.00±0.00 | 0.011 |
| Moderate | 186 | 4.64±0.85 | 4.62±0.91 | 0.02±0.27 | ||
| Severe | 25 | 3.28±1.81 | 3.12±1.72 | 0.16±0.37 | ||
Bold value indicates significant difference.
Average difference (Δ=D−ND) of strength between DH and NDH according disease severity (as assessed by CMTNS) is shown. Three subgroups were considered: mild (0–10); moderate (11–20); severe (21–36).
*Between CMTNS levels overall comparison by Kruskal–Wallis test.
APB, abductor pollicis brevis; AT, anterior tibialis; CMT, Charcot–Marie–Tooth; D, dominant side; DH, dominant hand; FDI, first dorsal interosseous; N, number of tested patients; ND, non-dominant side; NDH, non-dominant hand; TS, triceps surae.