Table 4

Linear mixed model parameter estimates (±SE) for MRI variables

MRI variable	Patients vs controls		Follow-up vs baseline		Change over time, patients vs controls
MRI variable	Estimate	p Value	Estimate	p Value	Estimate	p Value
Hippocampus*	−0.04±0.11	0.67	−0.31±0.11	0.007	0.09±0.15	0.55
Amygdala*	−0.12±0.06	0.06	−0.33±0.05	<0.001	0.07±0.08	0.34
WMHs*	0.02±0.00	<0.001	0.00±0.00	<0.001	0.00±0.00	0.71
Atrophy†	0.00±0.00	0.10	0.09±0.00	<0.001	0.10±0.00	0.04

*Estimates calculated using volume in mL and adjusted for age, sex and time-varying intracranial volume.
†Estimates adjusted for age and sex.
WMHs, white matter hyperintensities.