Univariate and multivariate analysis of determinants of early repolarisation pattern in cases (n=185) and controls (n=178)
| Epilepsy cohort (n=185) | Control cohort (n=178) | Crude OR (95% CI) | Adjusted OR (95% CI) (A) | Adjusted OR (95% CI) (B) | |
|---|---|---|---|---|---|
| Brugada ECG | 3 (2%) | 2 (1%) | 1.5 (0.2 to 8.8) | NA | NA |
| Severe QTc-prolongation | 10 (5%) | 0 (0%) | 21.0 (2.7 to 2708.2) | 9.9 (1.1 to 1317.7) | 9.9 (1.1 to 1317.7) |
| ERP | 62 (34%) | 23 (13%) | 3.4 (2.0 to 5.8) | 2.3 (1.0 to 5.5) | 2.4 (1.1 to 5.5) |
Dichotomous data are expressed as n (%) unless indicated otherwise. ORs are calculated using penalised logistic regression analysis (R statistical package) for severe QTc prolongation and logistic regression analysis for ERP. Covariates were entered in the analysis if they were associated (p<0.10) with pathological with severe QTc prolongation (see online supplementary table e-1) or ERP (see online supplementary table e-2).
A: all determinants that were univariately associated with severe QTc prolongation (gender, age, heart rate) or ERP (gender, heart disease, QT-prolonging drugs, depolarisation-blocking drugs, cardiovascular drugs, heart rate) were entered.
B: all determinants that changed the β by ≥5% and were univariately associated with severe QTc prolongation (gender, heart rate) or ERP (depolarisation-blocking drugs, heart rate) and changed the β by ≥5% were entered.
ERP, early repolarisation pattern.