Major phenotypic variants of CIDP
| CIDP phenotypic variant | Estimated prevalence within CIDP | Onset | Clinical symptoms | Distribution | References |
|---|---|---|---|---|---|
| Typical CIDP | 51% | Chronic | Sensory and motor | Symmetrical, proximal and distal | 8–10 |
| Sensory CIDP | 4–35% | Chronic | Sensory predominant; motor involvement may develop | As per typical CIDP | 5, 9–11 |
| Chronic immune sensory polyradiculopathy | 5–12% | Chronic | Sensory ataxia | As per typical CIDP | 8, 9, 12, 13 |
| Lewis-Sumner syndrome/ MADSAM | 6–15% | Chronic | Sensory and motor | Asymmetrical; often upper limb onset | 5, 8, 9, 14 |
| Focal CIDP | 1% | Chronic | Sensory and motor | Focal; may progress to diffuse CIDP over time | 9, 15 |
| DADS | 2–17% | Chronic | Sensory predominant, but may include motor involvement | Symmetrical, distal | 5, 9, 10 |
| Acute onset CIDP | 2–16% | Acute onset | As per typical CIDP | As per typical CIDP | 9, 16–18 |
| Motor CIDP | 4–10% | Chronic | Motor predominant | As per typical CIDP | 5, 8, 9, 13 |
CIDP, Chronic inflammatory demyelinating polyradiculoneuropathy; DADS, distal acquired demyelinating symmetric; MADSAM, multifocal acquired demyelinating sensory and motor neuropathy.