Focal increases in [18F]GE-179 VT—individual patients versus 10 controls
| Patient ID | Probable localisation (EEG) | MRI | [18F]GE-179 VT increases | Cluster size (mm3/voxels) | Peak voxel coordinates (x, y, z; mm) | Zmax | Cluster level p (uncorrected) |
|---|---|---|---|---|---|---|---|
| 1 | L frontotemporal | R IFG lesion | L frontal | 7000/875 | −322 234 | 4.46 | <0.001 |
| 4 | Multifocal | Multiple tubers | Brainstem | 5152/644 | 08–28–38 | 4.58 | 0.001 |
| L temporal | 3264/408 | −32 04–36 | 4.09 | 0.007 | |||
| R temporal | 1720/215 | 18 04–30 | 3.97 | 0.039 | |||
| 5 | Bilateral temporal L>R | Negative | R frontal | 3360/420 | 381 024 | 4.43 | 0.006 |
| 7 | R frontal | Negative | L frontal | 5904/738 | −122 242 | 4.23 | 0.001 |
| R frontal | 4512/564 | 061 840 | 4.23 | 0.002 |
The cluster(s) reaching significance at p<0.05 uncorrected are listed. The contribution of global VT to variance was removed by an ANCOVA by group. Underline indicates concordance between the cluster of increase and the location of the presumed epileptogenic zone, where known.
ANCOVA, analysis of covariance; EEG, electroencephalography; ID, identifying number; IFG, inferior frontal gyrus; L/R, left/right; mm, millimeters; MRI, magnetic resonance imaging; VT, volume-of-distribution.