Baseline characteristics
| Total (n=2708) | Right (n=1327) | Left (n=1381) | p Value | |
|---|---|---|---|---|
| Demographic | ||||
| Age, years | 64 (13) | 64 (13) | 63 (13) | 0.55 |
| Female | 1011 (37%) | 494 (37%) | 517 (37%) | 0.94 |
| Chinese region | 1866 (69%) | 907 (68%) | 959 (69%) | 0.57 |
| Medical history* | ||||
| Intracerebral haemorrhage | 224 (8%) | 119 (9%) | 105 (8%) | 0.22 |
| Ischaemic stroke | 255 (9%) | 118 (9%) | 137 (10%) | 0.40 |
| Acute coronary syndrome | 82 (3%) | 48 (4%) | 34 (2%) | 0.10 |
| Hypertension | 1960 (72%) | 955 (72%) | 1005 (73%) | 0.67 |
| Diabetes | 293 (11%) | 149 (11%) | 144 (10%) | 0.54 |
| Medication history* | ||||
| Antihypertensive therapy | 1202 (44%) | 592 (45%) | 610 (44%) | 0.85 |
| Oral anticoagulation therapy | 82 (3%) | 48 (4%) | 34 (2%) | 0.10 |
| Antiplatelet therapy | 257 (10%) | 126 (10%) | 131 (9%) | 1.00 |
| Antithrombotic therapy | 326 (12%) | 168 (13%) | 158 (11%) | 0.36 |
| Lipid lowering therapy | 191 (7%) | 102 (8%) | 89 (6%) | 0.24 |
| Clinical features | ||||
| Median time from onset to randomisation, hour | 3.68 (2.78–4.71) | 3.69 (2.77–4.80) | 3.66 (2.80–4.62) | 0.32 |
| Systolic BP, mm Hg | 179 (17) | 178 (17) | 180 (17) | 0.02 |
| Diastolic BP, mm Hg | 101 (15) | 101 (15) | 101 (14) | 0.14 |
| Median GCS score | 14 (12–15) | 15 (13–15) | 14 (11–15) | <0.0001 |
| Median NIHSS score† | 11 (6–16) | 10 (6–14) | 12 (7–17) | <0.0001 |
| Glucose, mmol/L‡ | 7.1 (2.6) | 7.1 (2.6) | 7.1 (2.6) | 0.60 |
| CT findings | ||||
| Median haematoma volume, mL | 11.4 (6.3–20.3) | 11.5 (6.4–20.5) | 11.4 (6.3–20.1) | 0.78 |
| Haematoma location | 0.83 | |||
| Lobar | 282 (10%) | 136 (10%) | 146 (11%) | |
| Deep | 2426 (90%) | 1191 (90%) | 1235 (89%) | |
| Intraventricular extension | 774 (29%) | 391 (29%) | 383 (28%) | 0.34 |
| INTERACT2 participants | 2402 (89%) | 1180 (89%) | 1222 (88%) | 0.77 |
| Randomised intensive BP lowering therapy | 1348 (50%) | 674 (51%) | 674 (49%) | 0.32 |
Data are n (%), mean (SD) or median (IQR). p Values are based on a χ2 test or a Kruskal-Wallis test.
*Data were missing in 2 patients.
†Data were missing in 10 patients.
‡Data were missing in 154 patients.
BP, indicates blood pressure; GCS, Glasgow Coma Scale; INTERACT2, Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial-2; NIHSS, National Institutes of Health Stroke Scale.