HRs for prognostic factors for time to 12-month and time to 24-month remission
| Multivariable HR (95% CI) | |||
|---|---|---|---|
| Prognostic factor | Comparison | 12-month remission | 24-month remission |
| Febrile seizure history | Absent | NA | 1.00 |
| Present | 1.36 (0.93 to 2.00) | ||
| First degree relative with epilepsy | Absent | 1.00 | 1.00 |
| Present | 0.69 (0.54 to 0.89) | 0.78 (0.57 to 1.05) | |
| Age (years) | ≤7 | 1.00 | NA |
| (8 to 13) | 1.03 (0.99 to 1.06) | ||
| (14 to 19) | 1.07 (0.98 to 1.18) | ||
| (20 to 27) | 1.12 (0.97 to 1.29) | ||
| (28 to 50) | 1.23 (0.94 to 1.61) | ||
| >50 | 1.45 (0.89 to 2.37) | ||
| Neurological insult | Absent | 1.00 | 1.00 |
| Present | 0.67 (0.49 to 0.92) | 0.56 (0.37 to 0.84) | |
| Total number of tonic-clonic seizures before randomisation | 0 | 1.00 | 1.00 |
| 1 | 0.93 (0.90 to 0.96) | 0.98 (0.97 to 0.99) | |
| 2 | 0.89 (0.84 to 0.93) | 0.96 (0.94 to 0.99) | |
| 3–4 | 0.85 (0.79 to 0.91) | 0.94 (0.90 to 0.98) | |
| 5–6 | 0.81 (0.74 to 0.89) | 0.91 (0.85 to 0.96) | |
| 7–10 | 0.78 (0.70 to 0.87) | 0.86 (0.78 to 0.95) | |
| 11–20 | 0.73 (0.64 to 0.84) | 0.76 (0.64 to 0.90) | |
| >20 | 0.49 (0.35 to 0.67) | 0.06 (0.01 to 0.35) | |
| Seizure type | Generalised tonic-clonic seizures only | 1.00 | 1.00 |
| Absence seizures | 0.98 (0.52 to 1.83) | 0.71 (0.50 to 0.99) | |
| Myoclonic or absence seizures with tonic-clonic seizures | 0.56 (0.43 to 0.73) | 0.54 (0.39 to 0.75) | |
| Unclassified tonic-clonic seizures | 0.82 (0.64 to 1.06) | 1.00 (0.74 to 1.35) | |
| Other seizures | 0.81 (0.48 to 1.36) | 0.54 (0.31 to 0.94) | |
| Treatment | Valproate | 1.00 | 1.00 |
| Lamotrigine | 0.78 (0.63 to 0.98) | 0.68 (0.52 to 0.89) | |
| Topiramate | 0.85 (0.68 to 1.16) | 0.67 (0.51 to 0.88) | |