Experimental task performance of patient and healthy control groups
| C9ORF72 | MAPT | Sporadic-FTD | Healthy controls | |
|---|---|---|---|---|
| Tactile discrimination | ||||
| Number completing test | 5 | 6 | 3 | 9 |
| Mean (SD) threshold (mm) | 18.5 (4.1)* | 13.4 (2.6) | 10.3 (6.5) | 13.1 (3.2) |
| Range thresholds (mm) | 12–23 | 9–16 | 4–18 | 6–18 |
| Tendon vibration | ||||
| Number completing test | 4 | 5 | 4 | 12 |
| Baseline accuracy | ||||
| Mean (SD) angle† score (degrees) | 4.8 (3.4) | 5.8 (5.4) | 6.7 (4.2) | 2.4 (2.0) |
| Range angle scores (degrees) | 0.8–9.2 | 0.3–13.5 | 3.1–12.6 | 0.6–6.3 |
| Stimulation accuracy | ||||
| Mean (SD) angle score (degrees) | 15.5 (18) | 7.01 (3.2) | 4.84 (3.8) | 3.8 (3.7) |
| Range angle scores (degrees) | 4–43 | 4–11 | 1–9 | 0–10 |
| Rubber hand illusion | ||||
| Number completing test | 4 | 7 | 4 | 13 |
| Mean questionnaire score | 5 (1.8)* | 17.3 (5.2) | 16.5.4 (6.8) | 13.1 (7.1) |
| Range questionnaire scores | 3–7 | 9–21 | 7–21 | 3–21 |
| Self-non-self action attribution | ||||
| Number completing test | 5 | 6 | 5 | 13 |
| Tickle self | ||||
| Mean (SD) score (/10) | 7.2 (2.2)* | 9.8 (0.4) | 10 (0) | 9.8 (0.3) |
| Range scores | 5–10 | 9–10 | 10 | 9–10 |
| Tickle non-self synchronous | ||||
| Mean (SD) score (/10) | 4 (0.7) | 5.5 (1.5) | 5.4 (3.4) | 4.6 (3.2) |
| Range scores | 3– 5 | 3–7 | 1–10 | 0–9 |
| Tickle non-self asynchronous | ||||
| Mean (SD) score (/10) | 6.2 (3.5) | 9.1 (1.2) | 8.8 (2.7) | 9.9 (0.2) |
| Range scores | 1–9 | 7–10 | 10 | 9–10 |
Mean (SD) values shown for experimental task performance. Scores statistically different from control group performance at p<0.05 are in bold.
*Also significantly different from both other patient groups; C9ORF72, pathogenic expansions associated with C9ORF72; FTD, frontotemporal dementia; MAPT, pathogenic mutations in the microtubule-associated protein tau gene.
†All angle values are based on individual absolute mean values of deviation angle (see figure 2).