T2 lesion load and total and regional DIR GM lesions of patients, and MTR values within the spectroscopic voxels of patients and controls
| Controls | Patients | |
|---|---|---|
| T2 lesion load (mean (SD)) | – | 7.05 mL (7.60) |
| DIR lesions (median (range)) | ||
| Total grey matter lesions | – | 22 lesions (range 6–275) |
| Hippocampal lesions in the right hippocampal spectroscopic VOI | – | 0.5 lesions (range 0–3) |
| Thalamic lesions in the right thalamic VOI | – | 0 lesions (range 0–2) |
| Grey matter lesions in the cingulate cortex VOI | – | 0 lesions (range 0–12) |
| Grey matter lesions in the post. parietal VOI | – | 1 lesion (range 0–6) |
| Total GM lesions in each structure on DIR (median[range]) | ||
| Right hippocampal lesions | 0.5 lesions (range 0–3) | |
| Right thalamic lesions | 0 lesions (range 0–2) | |
| GM fraction (mean (SD)) | 0.45 (0.04) | 0.42 (0.02)* |
| MTR (mean (SD)) | ||
| MTR in the right hippocampal VOI | 33.1 (2.0) | 31.1 (4.4) |
| MTR in the right thalamic VOI | 30.8 (1.5) | 29.1 (2.8)* |
| MTR in the cingulate cortex VOI | 30.9 (1.1) | 28.6 (2.7)* |
| MTR in the posterior parietal VOI | 37.9 (0.9) | 35.3 (2.5)* |
Note that the number of DIR lesions in the patients’ hippocampus and thalamus was similar to those seen in the spectroscopic hippocampal and thalamic voxels.
*p<0.05.
DIR, double inversion recovery; GM, grey matter; MTR, magnetisation transfer ratio; VOI, spectroscopic volume of interest; WM, white matter.