Group | n | Allele frequency (%) | Genotypes (%) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
ε2 | ε3 | ε4 | ε2/ε2 | ε2/ε3 | ε2/ε4 | ε3/ε3 | ε3/ε4 | ε4/ε4 | ||
DLB | 156 | 5.1 | 62.8 | 32.1 | 0.6 | 4.5 | 4.5 | 41.0 | 40.4 | 9.0 |
F | 67 | 7.5 | 57.5 | 35.0 | 1.5 | 7.5 | 4.5 | 34.3 | 38.8 | 13.4 |
M | 89 | 3.4 | 66.8 | 29.8 | 0.0 | 2.2 | 4.5 | 46.1 | 41.6 | 5.6 |
AD | 519 | 5.8 | 51.3 | 42.9 | 0.2 | 6.2 | 5.0 | 27.2 | 42.2 | 19.3 |
F | 351 | 5.7 | 51.7 | 42.6 | 0.3 | 5.1 | 5.7 | 28.2 | 41.9 | 18.8 |
M | 168 | 6.0 | 50.6 | 43.4 | 0.0 | 8.3 | 3.6 | 25.0 | 42.9 | 20.2 |
Healthy controls | 643 | 10.6 | 75.0 | 14.4 | 0.6 | 16.3 | 3.6 | 56.8 | 20.4 | 2.3 |
F | 388 | 10.2 | 75.5 | 14.3 | 0.5 | 15.7 | 3.6 | 57.2 | 20.9 | 2.1 |
M | 255 | 11.2 | 74.3 | 14.5 | 0.8 | 17.3 | 3.5 | 56.1 | 19.6 | 2.7 |
No significant difference in APOE allele and genotype frequencies between the TrønderBrain and DemVest cohorts, so all DLB patients have been pooled to a single group.
The APOE ε4 allele was significantly increased in both the DLB (p<0.0005) and AD patient groups (p<0.0005) compared with healthy controls, and was more common in AD than DLB (p=0.004). Conversely, the APOE ε2 allele was reduced in the DLB (p=0.002) and AD (p<0.0005) patient groups compared with controls (Pearson's χ2 test).
AD, Alzheimer's disease DLB, dementia with Lewy bodies.