DLB (total) | DLB (TrønderBrain) | DLB (DemVest) | AD (TrønderBrain) | Healthy controls (TrønderBrain) | |
---|---|---|---|---|---|
Cases (total) | 156 | 103 | 53 | 519 | 643 |
Probable/possible DLB | 135/21 | 88/15 | 47/6 | ||
Females (%) | 67 (42.9)*,† | 44 (42.7) | 23 (43.4) | 351 (67.6)* | 388 (60.3) |
Age at onset (y) | 72.3±7.9 | 72.3±7.7 | 72.1±8.3 | 71.3±9.3 | NA |
Age at inclusion (y) | 76.3±7.6* | 76.9±7.7 | 75.3±7.4 | 76.0±9.9* | 74.8±7.2 |
Duration (y) | 4.2±3.0† | 4.5±3.1 | 3.5±2.5 | 4.7±3.2 | NA |
Range of onset (y) | 46–89 | 46–88 | 50–89 | 47–88 | NA |
Mean education (y) | 9.8±3.1 | 9.9±3.1 | 9.6±3.0 | 9.5±3.1* | 9.8±2.9 |
MMSE | 19.6±7.5 | 17.9±8.4‡ | 22.9±3.3 | 17.8±8.1† | NA |
UPDRS III | 16.9±12.9† | 18.7±12.3‡ | 13.9±13.6 | 3.3±6.0 (n=294) | NA |
Statistical analysis was initially made using the Kruskal–Wallis test for multiple groups. Where values of p<0.05 were found, subsequent individual group comparisons were made with the Mann–Whitney U test.
All p values ≤0.03.
*Significant difference between a patient group and the control group.
†Significant difference between the groups of patients with DLB or AD.
‡Significant difference between the two DLB cohorts.
AD, Alzheimer's disease; DLB, dementia with Lewy bodies; MMSE, Mini Mental State Examination; UPDRS, Unified Parkinson's Disease Rating Scale.