Overall HR (95% CI) | Inadequate seizure control HR (95% CI) | Unacceptable adverse events HR (95%CI) | |
---|---|---|---|
Treatment history | |||
Treatment naive | 1.00 | 1.00 | 1.00 |
Seizures after remission | 2.05 (1.17 to 3.60) | 0.53 (0.12 to 2.28) | 2.42 (1.13 to 5.18) |
Taking non-SANAD AED | 1.10 (0.71 to 1.71) | 2.02 (1.13 to 3.60) | 0.72 (0.35 to 1.49) |
EEG result | |||
Normal | 1.00 | 1.00 | 1.00 |
Not done | 2.37 (1.38 to 4.05) | 1.83 (0.68 to 4.95) | 1.88 (0.90 to 3.89) |
Non-specific abnormality | 0.87 (0.52 to 1.47) | 1.23 (0.51 to 2.98) | 0.87 (0.44 to 1.74) |
Epileptiform abnormality | 1.13 (0.82 to 1.56) | 1.98 (1.12 to 3.52) | 0.85 (0.56 to 1.29) |
Seizure type | |||
Generalised tonic-clonic seizures only | 1.00 | 1.00 | 1.00 |
Absence seizures | 1.55 (1.07 to 2.25) | 3.36 (1.98 to 5.72) | 0.70 (0.39 to 1.27) |
Myoclonic or absence seizures with tonic-clonic seizures | 1.47 (1.04 to 2.08) | 2.03 (1.17 to 3.52) | 1.06 (0.64 to 1.76) |
Unclassified tonic-clonic seizures | 1.14 (0.79 to 1.63) | 1.09 (0.57 to 2.08) | 1.20 (0.75 to 1.91) |
Other seizures | 1.84 (1.13 to 3.00) | 1.92 (0.84 to 4.39) | 1.53 (0.78 to 3.00) |
Treatment | |||
Valproate | 1.00 | 1.00 | 1.00 |
Lamotrigine | 1.34 (0.98 to 1.83) | 2.14 (1.33 to 3.46) | 0.76 (0.47 to 1.23) |
Topiramate | 1.77 (1.32 to 2.39) | 1.76 (1.07 to 2.88) | 1.59 (1.06 to 2.38) |
SANAD, Standard and New Antiepileptic Drug.