Table 2

Antibodies to myelin proteins and nodal antigens in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

Candidate antigenPositive sera/total testedIg ClassMethodReference
Myelin proteins
 P06/21
4/21		IgGWestern blotting
IF on normal nerve		113
6/32IgG (3), IgA (3)Western blotting114
6/36*IgGELISA115
5/32
0/32		IgM
IgG		ELISA116
7/30*IgGELISA117
0/20*ELISA118
1/24*Western blotting119
3/40*
2/40*		IgG
IgM		ELISA120
 P211/32*
4/32*		IgM
IgG		ELISA116
4/36*IgGELISA115
4/30IgGELISA117
3/20*ELISA118
 PMP223/30*IgGELISA117
0/24*Western blotting119
7/17
6/17		Ig (3), IgM (3), pan Ig (1)ELISA
Western blotting		121
3/6*Western blotting122
 Cx321/24*Western blotting119
 MBP2/40*IgGELISA120
Nodal antigens
 Neurofascin 1554/61IgG4ELISA123
5/117IgG4, IgG3; IgM, IgAELISA124
CIDP 0/16*
CCPD 5/7
CIDP 4/16*
CCPD 6/7		IgGCell-based assay

ELISA		125
 Neurofascin 1861/50*IgGCell-based assay126
0/117*ELISA124
 Contactin-13/46†IgGCell-based assay127
1/50*IgGCell-based assay126

  • *Frequency not significantly higher than in healthy controls or other neuropathy controls.

  • †Contactin-1/caspr-1 in one patient.

  • CCPD, combined central and peripheral demyelination; IF, immunofluorescence.