Clinical and stimulation details of patients
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Mean+SEM | |
|---|---|---|---|---|---|
| Age (years) | 66 | 41 | 52 | 54 | 53.3±5.1 |
| Disease duration (years) | 6 | 7 | 8 | 25 | 11.5±4.5 |
| Preoperative UPDRS off-drugs | 49 | 50 | 40 | 32 | 42.8±4.2 |
| Preoperative UPDRS on-drugs | 19 | 21 | 11 | 4 | 13.8±3.9 |
| Surgery location | Oxford | London | London | London | |
| Initial symptom | Tremor | Bradykinesia | Tremor | Rigidity | |
| Primary DBS indication | Refractory tremor | ON-OFF fluctuations | Severe OFF states | OFF-related dystonia | |
| Preoperative drugs (mg/day) | Levodopa 1000 Pramipexole 3.15 | Levodopa 625 Amantadine 100 | Levodopa 500 Rotigotine 4 | Levodopa 1600 Pramipexole 0.375 Tolcapone 800 | |
| Online digital filter range (Hz) | 20±3 | 21±3 | 25±3 | 20±6 | 21.5±0.8 |
| Stimulation voltage (V, L/R) | 3.4/3.4 | 3.4/3.3 | 2.5/2.4 | 3.0/3.0 | 3.0±0.1 |
| aDBS ToS (%, L/R) | 25/38 | 53/52 | 35/36 | 62/60 | 45.0±4.8 |
aDBS, adaptive deep brain stimulation; L, left; R, right; SEM, SE of the mean; ToS, time on stimulation; UPDRS, Unified Parkinson's Disease Rating Scale Part III (motor).