Main characteristics of patients with GLUT1-DS during the baseline, treatment and withdrawal phases
| Patients | Mean | ||||||
|---|---|---|---|---|---|---|---|
| P1 | P2 | P3 | P4 | P5 | P6 | ||
| Sex | F | F | M | M | M | M | |
| Age | 23 | 20 | 7 | 14 | 16 | 47 | 21.2 |
| Baseline | |||||||
| Total events | 10 | 20 | 13 | 26 | 31 | 85 | 30.8 |
| Motor events | 6 | 16 | 10 | 1 | 12 | 54 | 16.5 |
| 6MWT (m) | 502 | 558 | 458 | 514 | 471 | 504 | 501 |
| 9HPT(D/ND) (s) | 17/18 | 18/23 | 19/21 | 15/17 | 18/22 | 14/16 | 17/19 |
| Treatment | |||||||
| Total events | 4 | 7 | 5 | 0 | 1 | 0 | 2.8 |
| Motor events | 2 | 7 | 3 | 0 | 1 | 0 | 2.2 |
| 6MWT (m) | 453 | 580 | 425 | 484 | 496 | 500 | 490 |
| 9HPT(D/ND) (s) | 17/19 | 17/20 | 19/19 | 17/21 | 17/18 | 15/18 | 17/19 |
| Withdrawal | |||||||
| Total events | 10 | 11 | 5 | 20 | 36 | 63 | 24.2 |
| Motor events | 9 | 9 | 1 | 1 | 15 | 40 | 12.5 |
| 6MWT (m) | 532 | 528 | 461 | 496 | 475 | 510 | 500 |
| 9HPT(D/ND) (s) | 15/22 | 14/20 | 17/17 | 17/19 | 18/20 | 15/15 | 16/19 |
Total events: all motor and non-motor paroxysmal manifestations during each 2-month-phase. Motor events: all motor paroxysmal episodes during each 2-month-phase. 6MWT: Total distance walked (metres). 9HPT-D: the best score (seconds) obtained with the dominant hand. 9HPT-ND: best score (seconds) with the non-dominant hand.
GLUT1-DS, glucose transporter type 1 deficiency syndrome; 6MWT, 6 min walk test; 9HPT, nine-hole pegboard test