Table 1
Current approaches and future directions in the application of iPSCs
| Mechanism | Therapeutics | Diagnostic | Cellular therapy | |
|---|---|---|---|---|
| Current progress | Pathophysiological clues in iPSC-derived neurons | Tests of potential therapeutic compounds in iPSC-derived neurons | Pathological changes in iPSC-derived neurons may have diagnostic potential | Success of dopamine neuron graft in animal models |
 | ||||
| Future research | Validation studies to confirm and identify new mechanisms | Screening drugs in iPSC-derived neurons in individual patients | Identification of biochemical markers with the aid of iPSC technology | Graft of HLA-matched neurons in clinical patients |
HLA, human leucocyte antigen; iPSC, induced pluripotent stem cells.