Number of patients reporting side effects in melatonin, amitriptyline and placebo groups
| Side effect | Melatonin (n=60) | Amitriptyline (n=59) | Placebo (n=59) |
|---|---|---|---|
| Sleepiness | 11 | 24 | 7 |
| Pruritus | 1 | 0 | 0 |
| Dizziness | 0 | 3 | 1 |
| Epigastralgia | 2 | 5 | 0 |
| Weight gain | 0 | 3 | 1 |
| Dry mouth | 1 | 6 | 1 |
| Insomnia | 0 | 1 | 0 |
| Constipation | 1 | 4 | 4 |
| Worsening headache | 0 | 0 | 3 |