Respondents | Person-years | ALS deaths | HR (95% CI)* | |
---|---|---|---|---|
Intensity | ||||
Unexposed | 607 416 | 9 815 195 | 372 | 1.0 (Reference) |
Low | 97 301 | 1 641 068 | 55 | 0.99 (0.74 to 1.30) |
Medium | 86 766 | 1 427 789 | 43 | 0.63 (0.44 to 0.90) |
High | 3058 | 46 188 | 2 | 1.53 (0.40 to 5.80) |
Intensity, exposed restricted to probability=high | ||||
Unexposed | 607 416 | 9 815 195 | 372 | 1.0 (Reference) |
Low | 0 | 0 | 0 | – |
Medium | 361 | 6954 | 0 | – |
High | 493 | 8539 | 2 | 4.43 (1.16 to 16.85) |
Probability | ||||
Unexposed | 607 416 | 9 815 195 | 372 | 1.0 (Reference) |
Low | 98 228 | 1 681 862 | 51 | 0.85 (0.63 to 1.15) |
Medium | 88 043 | 1 417 659 | 47 | 0.76 (0.54 to 1.06) |
High | 854 | 15 493 | 2 | 2.98 (0.78 to 11.30) |
Probability, excluding first 5 years of follow-up | ||||
Unexposed | 492 489 | 9 501 370 | 331 | 1.0 (Reference) |
Low | 82 155 | 1 637 260 | 47 | 0.87 (0.64 to 1.18) |
Medium | 71 598 | 1 372 603 | 39 | 0.77 (0.54 to 1.10) |
High | 758 | 15 230 | 2 | 3.49 (0.92 to 13.26) |
Probability, follow-up to age 75 only | ||||
Unexposed | 604 116 | 9 794 521 | 332 | 1.0 (Reference) |
Low | 97 959 | 1 680 822 | 41 | 0.79 (0.57 to 1.11) |
Medium | 86 760 | 1 407 671 | 40 | 0.66 (0.44 to 0.99) |
High | 832 | 15 315 | 2 | 4.13 (1.09 to 15.69) |
Probability, respondents 35≤age≤75 at enrolment | ||||
Unexposed | 427 530 | 6 493 151 | 332 | 1.0 (Reference) |
Low | 65 736 | 1 046 575 | 47 | 0.91 (0.67 to 1.24) |
Medium | 60 675 | 921 096 | 43 | 0.79 (0.56 to 1.12) |
High | 568 | 9731 | 2 | 3.41 (0.89 to 13.01) |
Probability, respondents 50≤age≤75 at enrolment | ||||
Unexposed | 175 376 | 2 441 370 | 197 | 1.0 (Reference) |
Low | 25 611 | 377 534 | 31 | 1.00 (0.67 to 1.49) |
Medium | 27 247 | 393 151 | 27 | 0.75 (0.47 to 1.19) |
High | 270 | 4125 | 2 | 4.76 (1.16 to 19.49) |
Probability, respondents employed at enrolment | ||||
Unexposed | 548 645 | 8 876 712 | 331 | 1.0 (Reference) |
Low | 85 041 | 1 459 452 | 45 | 0.88 (0.65 to 1.21) |
Medium | 76 249 | 1 238 082 | 38 | 0.71 (0.50 to 1.03) |
High | 770 | 14 063 | 2 | 3.26 (0.86 to 12.38) |
*Adjusted for race/ethnicity, education and household income as a percentage of the poverty line.
ALS, amyotrophic lateral sclerosis.