Seizure recurrence, remission, and mortality in people with cryptogenic/idiopathic seizures and those with symptomatic seizures
| Cryptogenic/idiopathic seizures | Remote symptomatic seizures | |
|---|---|---|
| N | 513 | 144 |
| Single seizure at presentation | 230 (45%) | 72 (50%) |
| Seizure recurrence | 336 (65%) | 107 (74%) |
| Probability of remaining seizure free at 10 years* | 0.36 (95% CI 0.32 to 0.40) | 0.23 (95% CI 0.16 to 0.31) |
| 3-year remission | N=488 with follow-up to 3 years | N=102 with follow-up to 3 years |
| Probability of remission by 5 years* | 0.72 (95% CI 0.68 to 0.76) | 0.58 (95% CI 0.49 to 0.68) |
| Probability of remission by 10 years* | 0.89 (95% CI 0.86 to 0.91) | 0.75 (95% CI 0.66 to 0.84) |
| Probability of remission by 15 years* | 0.92 (95% CI 0.89 to 0.94) | 0.87 (95% CI 0.77 to 0.94) |
| 5-year remission | N=477 with follow-up to 5 years | N=91 with follow-up to 5 years |
| Probability of remission by 5 years* | 0.40 (95% CI 0.36 to 0.45) | 0.26 (95% CI 0.19 to 0.37) |
| Probability of remission by 10 years* | 0.78 (95% CI 0.74 to 0.82) | 0.65 (95% CI 0.55 to 0.76) |
| Probability of remission by 15 years* | 0.86 (95% CI 0.82 to 0.89) | 0.75 (95% CI 0.64 to 0.84) |
| 5-year terminal remission | ||
| Number (%) in 5-year terminal remission at end of FU | 377/477 (79%; 95% CI 75 to 82) | 52/91 (57%; 95% CI 47 to 67) |
| Mortality | ||
| SMR whole cohort | 1.50 (95% CI 1.26 to 1.78) | 3.25 (95% CI 2.74 to 3.86) |
| SMR (single seizure at presentation) | 1.89 (95% CI 1.47 to 2.43) | 4.13 (95% CI 3.26 to 5.23) |
| SMR (epilepsy at presentation) | 1.25 (95% CI 0.97 to 1.60) | 2.59 (95% CI 2.01 to 3.32) |
| SMR (single notified seizure) | 1.49 (95% CI 1.02 to 2.19) | 1.72 (95% CI 1.03 to 2.85) |
*After the index seizure.
FU, follow-up; SMR, standardised mortality ratio.