Clinical data of patients with ALS and onset subtypes
| All | Bulbar onset | Limb onset | p Value* | |
|---|---|---|---|---|
| Patients with ALS, n | 131 | 46 | 85 | |
| Male/female ratio | 75:56 | 22:24 | 53:32 | NS |
| Age, years | ||||
| Mean | 61.0 | 65.3 | 58.5 | 0.009 |
| SD | 12.4 | 10.7 | 12.6 | |
| BMI | ||||
| Mean | 23.9 | 23.7 | 24.0 | NS |
| SD | 3.6 | 3.5 | 3.6 | |
| ALSFRS-R | ||||
| Mean | 32.21 | 31.78 | 32.46 | NS |
| SD | 8.50 | 9.50 | 7.93 | |
| Subscore 4 ALSFRS-R | ||||
| Mean | 10.31 | 10.04 | 10.46 | NS |
| SD | 2.00 | 1.98 | 2.02 | |
| Disease duration, months | ||||
| Mean | 20.55 | 20.22 | 20.73 | NS |
| SD | 12.89 | 12.70 | 12.91 | |
| Prevalence of dyspnoea, n | 74 | 30 | 44 | 0.05 |
| Prevalence of sleep problems, n | 50 | 22 | 28 | NS |
*p Values show differences between bulbar and limb onset by using t test.
ALS, amyotrophic lateral sclerosis; ALSFRS-R, ALS-Functional Rating Scale; BMI, body mass index; NS, non-significant.