Clinical correlates in 2611 recent-onset Parkinson's disease cases according to the use of statin medication
| Variable | Statin use, n=769 | No statin use, n=1842 | Unadjusted p value | Adjusted p value |
|---|---|---|---|---|
| Age | 71.1 (7.4) | 65.8 (9.4) | <0.001 | 0.16* |
| Sex | 573 (74.5%) | 1124 (61.0%) | <0.001 | 0.52† |
| Disease duration | 1.3 (0.9) | 1.3 (0.9) | 0.34 | 0.96‡ |
| UPDRS 3 | 25.3 (11.9) | 23.0 (11.6) | <0.001 | 0.97§ |
| Motor subtype | ||||
| TD | 361 (50.1%) | 835 (49.0%) | ||
| PIGD | 268 (37.2%) | 651 (38.2%) | 0.61 | 0.002§ |
| Mixed | 92 (12.8%) | 219 (12.8%) | 0.84 | 0.75§ |
| MoCA | ||||
| Total | 24.2 (3.7) | 25.5 (3.3) | <0.001 | <0.001§ |
| Normal | 450 (62.2%) | 1332 (76.9%) | <0.001 | 0.010§ |
| MCI | 120 (16.6%) | 206 (11.9%) | ||
| Dementia | 153 (21.2%) | 193 (11.1%) | ||
| LEDD | 291 (209) | 288 (207) | 0.71 | 0.035§ |
| Smoking | ||||
| Non-smoker | 352 (50.7%) | 1045 (61.5%) | <0.001 | 0.82§ |
| Ex-smoker | 319 (46.0%) | 589 (34.7%) | ||
| Current smoker | 23 (3.3%) | 65 (3.8%) | ||
Data are mean (SD) or number (percentage) unless otherwise stated.
*Adjusted for disease duration, sex and presence of existing cardiovascular disease or future cardiovascular risk.
†Adjusted for age, disease duration and presence of existing cardiovascular disease or future cardiovascular risk.
‡Adjusted for age, sex and presence of existing cardiovascular disease or future cardiovascular risk.
§Adjusted for age, sex, disease duration, coffee use and presence of existing cardiovascular disease or future cardiovascular risk.
MCI, mild cognitive impairment; MoCA, Montreal cognitive assessment; PIGD, postural instability gait difficulty; TD, tremor dominant; UPDRS3, Movement Disorder Society unified Parkinson's disease rating scale part 3.