Results on therapeutic trials on patients with sporadic Creutzfeldt-Jakob disease
| Active substance | Reference | Patients (n) | Study design | Prolongation of survival time | Further results |
|---|---|---|---|---|---|
| Amantadine | Terzano et al24 | 4 | Observational | No | Increased alertness |
| Neri et al25 | 8 | Observational | No | Increased alertness | |
| Flupirtine | Otto et al11 | 13 | Randomised controlled clinical trials | No | Less cognitive decline |
| Pentosan-polyphosphate | Bone et al26 | 7 | Observational | Possibly extended | |
| Tsuboi et al27 | 11 | Observational | Possibly extended | ||
| Quinacrine | Haik et al28 | 32 | Case–control | No | |
| Collinge et al17 | 40 | Observational | No | ||
| Geschwind et al18 | 23 | Observational | No | Less cognitive decline | |
| Doxycycline | Haik et al8 | 62 | Randomised controlled clinical trials | No |