Demographics, medical history, stroke characteristics and treatment process times
| Intravenous rtPA (IVT) | IVT+MT | |
|---|---|---|
| n | 32 | 33 |
| Age, years, mean±SD | 64±16 | 67±17 |
| >80 years, n (%) | 3 (9%) | 6 (18%) |
| Male, n (%) | 16 (50%) | 13 (39%) |
| Estimated prestroke mRS | ||
| 0 | 28 (88%) | 27 (82%) |
| 1 | 1 (3%) | 5 (15%) |
| ≥2 | 3 (9%) | 1 (3%) |
| Smoker (current), n (%) | 3 (9%) | 4 (12%) |
| MI or IHD, n (%) | 6 (19%) | 4 (12%) |
| Previous stroke, n (%) | 2 (6%) | 3 (9%) |
| Diabetes, n (%) | 6 (19%) | 11 (33%) |
| Hypertension, n (%) | 17 (53%) | 17 (52%) |
| Atrial fibrillation, n (%) | 8 (25%) | 15 (46%) |
| Prestroke antithrombotic therapy, n | ||
| Aspirin | 3 (9%) | 2 (6%) |
| Clopidogrel | 0 | 1 (3%) |
| Warfarin | 2 (6%) | 1 (3%) |
| Direct oral anticoagulant | 0 | 3 (9%) |
| Glucose, mmol/L (mean±SD) | 7.3 (3.4) | 8.0 (3.2) |
| Pretreatment systolic/diastolic BP mm Hg (mean±SD) | 144/83 (25/18) | 147/77 (23/15) |
| NIHSS median, range | 14 (6–29) | 18 (6–24) |
| ASPECTS median, range | 9 (2–10) | 9 (4–10) |
| 0–4, n (%) | 1 (3%) | 1 (3%) |
| 5–7, n (%) | 9 (28%) | 6 (18%) |
| 8–10, n (%) | 22 (69%) | 26 (79%) |
| CTA occlusion site, n (%) | ||
| ICA T/L±M1±M2 | 6 (19%) | 4 (14%) |
| MCA M1±M2 | 21 (65%) | 22 (76%) |
| MCA M2 | 5 (16%) | 3 (10%) |
| Collateral score, n (%) | ||
| Good | 12 (40%) | 18 (55%) |
| Moderate | 12 (40%) | 10 (30%) |
| Poor | 6 (20%) | 5 (15%) |
| Extracranial ICA occlusion present, n (%) | 1 (3%) | 1 (3%) |
| Clot burden score, median (IQR) | 6 (4, 7) | 7 (4, 8) |
| Process times, min, median (IQR) | ||
| Symptom onset to IVT start | 120 (62, 238) | 120 (61, 242) |
| Symptom onset to randomisation | 150 (88, 268) | 150 (78, 271) |
| IVT start to groin puncture | 82 (28, 140) | |
| Randomisation to groin puncture | 58 (12, 87) | |
| Groin puncture to device removal | 49 (15, 137) | |
| Total time, onset to procedure end | 251 (181, 390) | |
| Poststroke antithrombotic therapy, n | ||
| Aspirin | 17 (53%) | 20 (61%) |
| Clopidogrel | 10 (31%) | 11 (33%) |
| Warfarin | 1 (3%) | 2 (6%) |
| Direct oral anticoagulant | 2 (6%) | 3 (9%) |
ASPECTS, Alberta Stroke Programme Early CT Score; BP, blood pressure; CTA, CT angiography; ICA, internal carotid artery; IHD, ischaemic heart disease; IVT, intravenous thrombolysis; MCA, middle cerebral artery; MI, myocardial infarction; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NIHSS, National Institutes of Health Stroke Scale; rtPA, recombinant tissue plasminogen activator.