Table 1

Demographics, lesion details and baseline behavioural performance of the patients with aphasic stroke

IDGroupSexHand-
edness
SeverityAphasia
subtype
Age at baseline (years)Time since stroke (years)Type of strokeLesion volume (cm3)% of ROI damagedSpeech comprehensionSpeech production
Left A1Left STGCAT word comp. (/30)CAT sentence comp. (/32)Vowel ID
(/40)
CAT repetition
(/74)
CAT object naming (/48)
11MLMG69.61.0I69.51.80.0292827286
22MRMW62.71.2I42.47.221.13022383438
31MRMW638.6I429.381.043.32721175022
41MLMW61.57.6I314.052.90.02325163812
51MRMW67.87.4H64.38.130.52921375030
62MRMW60.55.6I161.152.79.32730345427
71MRMW64.91.2I171.139.717.92721386033
81MRSG61.41.9I242.952.652.62461600
92FRSG66.55.3I195.242.321.42115132312
101MRMW61.53.4M-L*1.60.00.02626406336
111MRSG63.30.6I69.08.333.520131200
122FRSG43.51.3I69.768.746.11417171814
132FRSW46.30.7I31.760.915.32612262641
142MRSG71.15.1I151.179.529.82014700
152MRSG62.43.7I168.620.20.0221121300
161MRMW60.93.0H136.611.71.52826406837
171MRMG45.43.7I61.25.816.72721393118
182MRMW74.70.6I41.17.32.92426244514
192MRMG50.21.8I280.529.50.9252639282
201MRMW90.33.7I62.914.20.02721346843
  • Behavioural measures included CAT spoken word comprehension (score cut-off for impaired performance=25), CAT spoken sentence comprehension (cut-off=27), vowel identification (36), CAT total repetition score (67) and CAT object naming (43). Values highlighted in bold indicate scores below the threshold for normal performance.

  • *Patient 10 had four small lacunes in the left hemisphere: (1) superior and lateral occipital lobe (I); (2) deep to the superior frontal sulcus (I); (3) superior longitudinal fasciculus (L) and (4) inferomedial thalamus (L).

  • †Patient 17 failed to escalate to 10 mg of donepezil in the second drug block and remained on 5 mg for both blocks.

  • CAT, comprehensive aphasia test; I, infarct; H, haemorrhagic; M-L, multilacune; ROI, region of interest; STG, superior temporal gyrus.