Table 2

Patient demographics

Younger
controls
Older
controls
EOAD PSEN1 LOAD DLB 3R-tau 4R-tau TDP43A TDP43C
N33406810292511171214
Sex (%male)30706560667272535050
Age at onset (years)NANA55.3 (5.7)39.6 (4.6)71.7 (6.0)67.1 (6.1)57.2 (6.3)61.4 (9.7)58.2 (6.5)61.6 (8.0)
Age at scan (years)59.9 (4.8)72.2 (5.2)60.5 (6.2)44.0 (4.2)75.8 (5.7)71.3 (6.0)62.6 (6.2)65.7 (9.3)60.3 (7.7)66.0 (6.6)
Disease duration
at scan (years)
NANA5.2 (2.9)4.4 (2.3)4.1 (2.1)4.2 (2.9)5.4 (2.1)4.4 (2.4)2.9 (2.4)4.5 (3.0)
MMSE (×/30)NANA18 (7)15 (6)19 (5)20 (5)21 (7)23 (5)17 (8)23 (6)
Time from scan
until death (years)
NANA5.8 (2.9)4.2 (2.2)5.7 (3.3)3.7 (2.3)6.0 (3.5)4.8 (2.3)5.2 (4.0)7.0 (3.4)
TIV (mL)1425 (121)1531 (156)1504 (155)1440 (163)1484 (136)1530 (149)1506 (164)1517 (178)1480 (133)1483 (165)
1.5 T scans79%73%77%80%86%76%91%76%50%86%
3.0 T scans21%27%13%20%7%8%9%24%33%7%
  • Data are reported as mean (SD).

  • DLB, dementia with Lewy bodies; EOAD, early-onset Alzheimer’s disease; LOAD, late-onset Alzheimer’s disease; MMSE, Mini-Mental State Examination (within 12 months of scanning); NA, not applicable; PSEN1, presenilin-1 mutation carriers; TDP43, transactive response DNA-binding protein 43; TIV, total intracranial volume;