Observed and expected number of deaths and standardised mortality ratios (SMR) by gender, disease course and periods for disease at onset, period for diagnosis, age at onset and age at diagnosis for patients with multiple sclerosis (MS) in Hordaland
| Group | N | Observed, n (%) | Expected, n (%) | SMR | (95 % CI) | p-value (log-rank) |
|---|---|---|---|---|---|---|
| All patients | 1388 | 291 (21.0) | 107.3 (7.7) | 2.7 | 2.4 to 3.0 | <0.0001 |
| Gender | 0.0009 | |||||
| Male | 533 | 131 (24.6) | 52.6 (9.9) | 2.5 | 2.1 to 2.9 | |
| Female | 855 | 160 (18.7) | 54.7 (6.4) | 2.9 | 2.5 to 3.4 | |
| Course of disease at onset | <0.0001 | |||||
| RRMS | 1209 | 202 (16.7) | 84.4 (7.0) | 2.4 | 2.1 to 2.7 | |
| PPMS | 179 | 89 (49.7) | 23.0 (12.8) | 3.9 | 3.1 to 4.7 | |
| Period for onset | 0.0083 | |||||
| 1953–1974 | 237 | 155 (65.4) | 49.8 (21.0) | 3.1 | 2.6 to 3.6 | |
| 1975–1996 | 638 | 130 (20.4) | 49.4 (7.7) | 2.6 | 2.2 to 3.1 | |
| 1997–2012 | 513 | 6 (1.1) | 8.1 (1.6) | 0.7 | 0.3 to 1.5 | |
| Period for diagnosis | <0.0001 | |||||
| 1953–1974 | 136 | 100 (73.5) | 33.4 (24.6) | 3 | 2.5 to 3.6 | |
| 1975–1996 | 602 | 178 (29.6) | 58.3 (9.7) | 3.1 | 2.6 to 3.5 | |
| 1997–2012 | 650 | 13 (2.0) | 15.7 (2.4) | 0.8 | 0.5 to 1.4 | |
| Age at onset (years) | <0.0001 | |||||
| 20 | 107 | 20 (18.7) | 2.7 (2.5) | 7.3 | 4.5 to 10.9 | |
| 21–30 | 471 | 90 (19.1) | 22.3 (4.7) | 4 | 3.3 to 4.9 | |
| 31–40 | 459 | 90 (19.6) | 35.2 (7.7) | 2.6 | 2.1 to 3.1 | |
| 41–50 | 246 | 61 (13.4) | 28.2 (6.2) | 2.2 | 1.7 to 2.8 | |
| 51–60 | 92 | 25 (27.2) | 15.0 (16.3) | 1.7 | 1.1 to 2.4 | |
| 61+ | 13 | 5 (38.5) | 3.9 (3.0) | 1.3 | 0.5 to 2.8 | |
| Age at diagnosis (years) | 0.0043 | |||||
| 20 | 49 | 6 (12.2) | 0. 7 (1.4) | 9 | 3.6 to 18.3 | |
| 21–30 | 327 | 57 (17.4) | 10.6 (3.2) | 5.4 | 4.1 to 6.9 | |
| 31–40 | 454 | 90 (19.8) | 25.5 (5.6) | 3.5 | 2.9 to 4.3 | |
| 41–50 | 356 | 81 (22.8) | 37.0 (10.4) | 2.2 | 1.7 to 2.7 | |
| 51–60 | 161 | 42 (26.1) | 24.3 (15.1) | 1.7 | 1.3 to 2.3 | |
| 61+ | 41 | 15 (36.6) | 9.2 (22.4) | 1.6 | 0.9 to 2.6 |
PPMS, primary progressive MS; RRMS, relapsing-remitting MS.