Summary data of review of the literature of patients with TBK1 variants
| No of patients (variants) | Clinical presentation* | M/F* | Mean age at onset ±SD (years)* | |||||
| ALS (fALS) | ALS-FTD | FTD | M+F | M | F | |||
| All | 110 (80) | 57 (17) | 16 | 19 | 45/39 | 60.4 ±10.9 | 58.1 ±11.3 | 62.0 ±10 |
| LoF | 59 (32) | 30 (13) | 10 | 12 | 30/24 | 62.5 ±9.7 | 61.0 ±9.6 | 64.3 ±9.7 |
*For some patients reported data are not complete. Extensive data are presented in online supplementary table 4.
ALS, amyotrophic lateral sclerosis; F, female; fALS, familial ALS; FTD, frontotemporal dementia; LoF, loss of function; M, male; TBK1, TANK-binding kinase 1.