Table 4

Baseline predictors of baseline NMS* in PD subjects

VariableUnivariate analysisNumber of observations missingMultivariable analysis
Parameter estimate (95% CI)p-ValueParameter estimate (95% CI)p-Value
Age0.022 (−0.018 to 0.063)0.27600
Gender (male)−0.828 (−1.644 to 0.013)0.04650−0.952 (−1.659 to 0.245)0.0084
Education (<13 years)−0.491 (−1.503 to 0.521)0.34090
Ethnicity (hispanic)−0.472 (−3.166 to 2.221)0.73050
Race (white)−0.833 (−2.302 to 0.635)0.26510
Family history of PD0.020 (−0.887 to 0.927)0.96561
Age-adjusted/sex-adjusted UPSIT (Anosmia)0.832 (0.019 to 1.645)0.04490NSNS
MDS-UPDRS Part II Score0.497 (0.417 to 0.577)<0.000100.443 (0.351 to 0.534)<0.0001
MDS-UDPRS Part III Score0.091 (0.048 to 0.134)<0.00010NSNS
Modified Schwab and England Activities of Daily Living Scale−0.209 (−0.273 to 0.146)<0.00010NSNS
Hoehn and Yahr (Stage 1)−1.002 (−1.780 to 0.223)0.01180NSNS
TD/non-TD classification−1.382 (−2.228 to 0.536)0.00140Not includedNot included
PIGD score6.522 (4.896 to 8.149)<0.000102.358 (0.645 to 4.072)0.0071
Tremor score0.857 (−0.371 to 2.084)0.17080NSNS
Side most affected (Left)−0.038 (−0.765 to 0.688)0.91720
Disease duration0.033 (−0.028 to 0.093)0.28700
Age of PD onset0.021 (−0.019 to 0.060)0.30278
Contralateral caudate−0.698 (−1.400 to 0.003)0.05095NSNS
Ipsilateral caudate−0.460 (−1.122 to 0.202)0.17255Not includedNot included
Contralateral putamen0.162 (−1.289 to 1.613)0.82625
Ipsilateral putamen−0.412 (−1.436 to 0.612)0.42995
A-Beta−0.001 (−0.005 to 0.002)0.445811
t-tau0.002 (−0.001, to 0.005)0.225715
p-tau−0.001 (−0.005 to 0.002)0.473813
t-tau/A-Beta0.004 (0.0001 to 0.007)0.0389150.003 (−0.0001 to 0.006)0.0611
p-tau/A-Beta−0.000 (−0.004 to 0.003)0.792313
p-tau/t-tau−0.003 (−0.007 to 0.0001)0.046217NSNS
α-Synuclein0.001 (−0.002 to 0.005)0.437011
  • Report generated on data submitted as of 4 January 2016.

  • *NMS is defined as MDS-UPDRS Part I Score.

  • Note: TD/non-TD classification was not included in the multivariable model because tremor and PIGD scores were already being considered.

  • Similarly, ipsilateral caudate was not included in the multivariable model because contralateral caudate was already being considered.

  • MDS-UPDRS, Movement Disorder Society Unified Parkinson’s Disease Rating Scale; NMS, non-motor symptoms; PD, Parkinson’s disease; PIGD, postural instability gait disorder; TD, tremor dominant; UPSIT, University of Pennsylvania Smell Identification Test.