Table 2

MDS-UPDRS Part I at baseline, year 1 and year 2

VariablePD subjectsHealthy controls (HC)p-Values
Baseline (n=423)Year 1 (n=398)Year 2 (n=380)p Value (change over time)Baseline (n=196)Year 1 (n=185)Year 2 (n=174)p Value (change over time)Group*Visit
Interaction
PD versus HC
MDS-UPDRS Part I score
 Mean (SD)5.57 (4.06)6.78 (4.60)7.68 (5.02)<0.00012.94 (2.96)3.21 (3.21)3.18 (3.03)0.3817<0.0001N/A*
 (Min, Max)(0.00, 24.00)(0.00, 29.00)(0.00, 26.00)(0.00, 17.00)(0.00, 16.00)(0.00, 14.00)
  Missing134101
Cognitive impairment
 Normal315 (74.64%)279 (71.36%)242 (64.36%)0.0007176 (90.26%)170 (91.89%)149 (86.13%)0.13540.5412<0.0001
  Slight94 (22.27%)95 (24.30%)102 (27.13%)18 (9.23%)15 (8.11%)24 (13.87%)
  Mild13 (3.08%)15 (3.84%)25 (6.65%)1 (0.51%)0 (0.00%)0 (0.00%)
 Moderate0 (0.00%)2 (0.51%)7 (1.86%)0 (0.00%)0 (0.00%)0 (0.00%)
  Severe0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)
Hallucinations and psychosis
  Normal409 (96.92%)372 (95.14%)347 (92.29%)0.0057194 (99.49%)185 (100.00%)171 (98.84%)N/A†N/A†<0.0001
  Slight13 (3.08%)19 (4.86%)24 (6.38%)1 (0.51%)0 (0.00%)2 (1.16%)
  Mild0 (0.00%)0 (0.00%)4 (1.06%)0 (0.00%)0 (0.00%)0 (0.00%)
 Moderate0 (0.00%)0 (0.00%)1 (0.27%)0 (0.00%)0 (0.00%)0 (0.00%)
  Severe0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)
Depressed mood
  Normal322 (76.30%)277 (70.84%)260 (69.15%)0.0111171 (87.69%)163 (88.11%)153 (88.44%)0.90700.2815<0.0001
  Slight85 (20.14%)86 (21.99%)81 (21.54%)21 (10.77%)16 (8.65%)16 (9.25%)
  Mild14 (3.32%)23 (5.88%)23 (6.12%)2 (1.03%)4 (2.16%)4 (2.31%)
 Moderate0 (0.00%)5 (1.28%)10 (2.66%)0 (0.00%)2 (1.08%)0 (0.00%)
  Severe1 (0.24%)0 (0.00%)2 (0.53%)1 (0.51%)0 (0.00%)0 (0.00%)
Anxious mood
  Normal271 (64.22%)257 (65.73%)253 (67.29%)0.5020157 (80.51%)155 (83.78%)147 (84.97%)0.27480.6480<0.0001
  Slight130 (30.81%)101 (25.83%)95 (25.27%)34 (17.44%)24 (12.97%)23 (13.29%)
  Mild17 (4.03%)29 (7.42%)18 (4.79%)3 (1.54%)6 (3.24%)3 (1.73%)
 Moderate3 (0.71%)4 (1.02%)9 (2.39%)1 (0.51%)0 (0.00%)0 (0.00%)
  Severe1 (0.24%)0 (0.00%)1 (0.27%)0 (0.00%)0 (0.00%)0 (0.00%)
Apathy
 Normal351 (83.18%)301 (76.98%)278 (73.94%)0.0002186 (95.38%)178 (96.22%)165 (95.38%)0.89190.3936<0.0001
  Slight60 (14.22%)62 (15.86%)63 (16.76%)8 (4.10%)6 (3.24%)7 (4.05%)
  Mild10 (2.37%)25 (6.39%)27 (7.18%)1 (0.51%)1 (0.54%)1 (0.58%)
  Moderate0 (0.00%)3 (0.77%)7 (1.86%)0 (0.00%)0 (0.00%)0 (0.00%)
  Severe1 (0.24%)0 (0.00%)1 (0.27%)0 (0.00%)0 (0.00%)0 (0.00%)
Dopamine dysregulation syndrome
  Normal413 (97.87%)382 (97.70%)353 (94.13%)0.0188192 (98.46%)185 (100.00%)171 (98.84%)N/A†N/A†0.0006
  Slight8 (1.90%)7 (1.79%)17 (4.53%)3 (1.54%)0 (0.00%)2 (1.16%)
  Mild1 (0.24%)2 (0.51%)5 (1.33%)0 (0.00%)0 (0.00%)0 (0.00%)
 Moderate0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)
  Severe0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)
Sleep problems
  Normal198 (46.92%)163 (41.69%)152 (40.43%)0.0655110 (56.41%)94 (50.81%)95 (54.91%)0.29500.38150.0010
  Slight125 (29.62%)106 (27.11%)100 (26.60%)53 (27.18%)55 (29.73%)39 (22.54%)
  Mild62 (14.69%)79 (20.20%)80 (21.28%)19 (9.74%)23 (12.43%)24 (13.87%)
 Moderate26 (6.16%)35 (8.95%)31 (8.24%)10 (5.13%)11 (5.95%)13 (7.51%)
  Severe11 (2.61%)8 (2.05%)13 (3.46%)3 (1.54%)2 (1.08%)2 (1.16%)
Daytime sleepiness
  Normal213 (50.47%)150 (38.36%)118 (31.38%)<0.0001127 (65.13%)117 (63.24%)102 (58.96%)0.23320.0228N/A*
  Slight123 (29.15%)133 (34.02%)132 (35.11%)49 (25.13%)42 (22.70%)46 (26.59%)
  Mild84 (19.91%)106 (27.11%)119 (31.65%)18 (9.23%)25 (13.51%)25 (14.45%)
 Moderate2 (0.47%)1 (0.26%)4 (1.06%)1 (0.51%)1 (0.54%)0 (0.00%)
  Severe0 (0.00%)1 (0.26%)3 (0.80%)0 (0.00%)0 (0.00%)0 (0.00%)
Pain and other sensations
  Normal201 (47.63%)168 (42.97%)142 (37.77%)0.0034130 (66.67%)114 (61.96%)112 (64.74%)0.48740.2124<0.0001
  Slight168 (39.81%)151 (38.62%)171 (45.48%)53 (27.18%)55 (29.89%)46 (26.59%)
  Mild32 (7.58%)39 (9.97%)38 (10.11%)5 (2.56%)7 (3.80%)9 (5.20%)
 Moderate17 (4.03%)30 (7.67%)19 (5.05%)6 (3.08%)7 (3.80%)6 (3.47%)
  Severe4 (0.95%)3 (0.77%)6 (1.60%)1 (0.51%)1 (0.54%)0 (0.00%)
Urinary problems
  Normal207 (49.05%)170 (43.48%)160 (42.55%)0.0228148 (75.90%)139 (75.54%)133 (76.88%)0.90050.3128<0.0001
  Slight165 (39.10%)160 (40.92%)142 (37.77%)39 (20.00%)33 (17.93%)31 (17.92%)
  Mild35 (8.29%)45 (11.51%)52 (13.83%)6 (3.08%)11 (5.98%)8 (4.62%)
 Moderate11 (2.61%)14 (3.58%)19 (5.05%)2 (1.03%)1 (0.54%)1 (0.58%)
  Severe4 (0.95%)2 (0.51%)3 (0.80%)0 (0.00%)0 (0.00%)0 (0.00%)
Constipation
  Normal282 (66.82%)206 (52.69%)187 (49.73%)<0.0001171 (87.69%)161 (87.03%)153 (88.44%)0.77790.0272N/A*
  Slight109 (25.83%)139 (35.55%)135 (35.90%)21 (10.77%)22 (11.89%)18 (10.40%)
  Mild26 (6.16%)36 (9.21%)40 (10.64%)2 (1.03%)2 (1.08%)2 (1.16%)
 Moderate5 (1.18%)10 (2.56%)14 (3.72%)1 (0.51%)0 (0.00%)0 (0.00%)
  Severe0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)0 (0.00%)
Lightheadedness
  Normal311 (73.70%)274 (70.08%)244 (64.89%)0.0061175 (89.74%)163 (88.11%)157 (90.75%)0.67030.2232<0.0001
  Slight96 (22.75%)97 (24.81%)99 (26.33%)20 (10.26%)19 (10.27%)16 (9.25%)
  Mild12 (2.84%)18 (4.60%)23 (6.12%)0 (0.00%)3 (1.62%)0 (0.00%)
 Moderate3 (0.71%)2 (0.51%)9 (2.39%)0 (0.00%)0 (0.00%)0 (0.00%)
  Severe0 (0.00%)0 (0.00%)1 (0.27%)0 (0.00%)0 (0.00%)0 (0.00%)
Fatigue
  Normal210 (49.76%)181 (46.29%)161 (42.82%)0.0524146 (74.87%)131 (70.81%)119 (68.79%)0.29920.9097<0.0001
  Slight165 (39.10%)144 (36.83%)138 (36.70%)44 (22.56%)46 (24.86%)48 (27.75%)
  Mild34 (8.06%)51 (13.04%)62 (16.49%)2 (1.03%)5 (2.70%)6 (3.47%)
 Moderate10 (2.37%)13 (3.32%)12 (3.19%)3 (1.54%)3 (1.62%)0 (0.00%)
  Severe3 (0.71%)2 (0.51%)3 (0.80%)0 (0.00%)0 (0.00%)0 (0.00%)
Cognitive/psychiatric subdomain
 Mean (SD)1.23 (1.57)1.53 (1.85)1.87 (2.27)<0.00010.54 (1.08)0.48 (1.13)0.52 (1.01)0.6261<0.0001N/A*
 (Min, Max)(0.00, 13.00)(0.00, 10.00)(0.00, 14.00)(0.00, 8.00)(0.00, 8.00)(0.00, 5.00)
  Missing174101
  Score=0177 (41.94%)150 (38.36%)129 (34.31%)137 (70.26%)140 (75.68%)122 (70.52%)
 One or above245 (58.06%)241 (61.64%)247 (65.69%)0.029058 (29.74%)45 (24.32%)51 (29.48%)0.21690.1156<0.0001
 Two or above134 (31.75%)148 (37.85%)164 (43.62%)0.000127 (13.85%)18 (9.73%)20 (11.56%)0.29250.0204N/A*
Sleep subdomain
 Mean (SD)1.58 (1.49)1.93 (1.55)2.13 (1.60)<0.00011.13 (1.30)1.28 (1.30)1.33 (1.39)0.07370.0089N/A*
 (Min, Max)(0.00, 7.00)(0.00, 8.00)(0.00, 8.00)(0.00, 6.00)(0.00, 5.00)(0.00, 6.00)
  Missing174101
  Score=0123 (29.15%)87 (22.25%)70 (18.62%)83 (42.56%)63 (34.05%)64 (36.99%)
  One or above299 (70.85%)304 (77.75%)306 (81.38%)0.0003112 (57.44%)122 (65.95%)109 (63.01%)0.10010.2159<0.0001
  Two or above187 (44.31%)221 (56.52%)235 (62.50%)<0.000163 (32.31%)63 (34.05%)67 (38.73%)0.23300.0259N/A*
Autonomic subdomain
 Mean (SD)1.40 (1.37)1.74 (1.48)1.99 (1.70)<0.00010.54 (0.81)0.59 (0.86)0.51 (0.85)0.4648<0.0001N/A*
 (Min, Max)(0.00, 7.00)(0.00, 10.00)(0.00, 8.00)(0.00, 4.00)(0.00, 4.00)(0.00, 5.00)
  Missing174101
 Score=0127 (30.09%)88 (22.51%)75 (19.95%)120 (61.54%)111 (60.00%)113 (65.32%)
  One or above295 (69.91%)303 (77.49%)301 (80.05%)0.000275 (38.46%)74 (40.00%)60 (34.68%)0.33270.0060N/A*
  Two or above162 (38.39%)198 (50.64%)209 (55.59%)<0.000121 (10.77%)26 (14.05%)19 (10.98%)0.41750.0432N/A*
  • Report generated on data submitted as of 04 January 2016.

  • p Values for individual Part I items are from logistic models considering response=0 versus any other response.

  • *PD versus HC comparison is not applicable if test of interaction was significant. A significant test of interaction means the rates of change over time are different between the two groups.

  • †Test could not be performed because all subjects from one group are in only one category for at least one time point.

  • MDS-UPDRS, Movement Disorder Society Unified Parkinson’s Disease Rating Scale; N/A, not applicable;PD, Parkinson’s disease.