Features supporting and contravening diagnosis of Perry syndrome
| Clinical features | Laboratory features | ||
| Supporting features | Non-supporting features | Supporting features | Non-supporting features |
| (1) Frontal signs | (1) Hypoxia and hypercapnia due to cardiac and pulmonary diseases | (1) MRI/CT: normal or frontotemporal atrophy | (1) Genetic test: mutation in the MAPT gene |
| (2) Oculomotor disorders | (2) Seizures | (2) Functional imaging: reduction of striatal tracer uptake | (2) Pathology: evidence of other neurodegenerative diseases |
| (3) Cognitive impairment | (3) Myoclonus | (3) Cardiac MIBG scintigraphy: decreased uptake | |
| (4) Autonomic dysfunction | (4) Cerebellar ataxia | (4) Functional imaging: frontotemporal hypometabolism | |
| (5) Sleep disturbances | (5) Sensory impairment | ||
| (6) Amyotrophy | |||
MIBG, [123I]-metaiodobenzylguanidine.