Biochemical and Biophysical Research Communications
Volume 225, Issue 2, 14 August 1996, Pages 474-478
Regular ArticleSynergistic Induction of Nitric Oxide by β-Amyloid and Cytokines in Astrocytes
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Cited by (131)
Amyloid beta acts synergistically as a pro-inflammatory cytokine
2021, Neurobiology of DiseaseCitation Excerpt :These observations highlight the point that pro-inflammatory cytokines act in concert in vivo (Gouwy et al., 2005), which could suggest that the pro-inflammatory activity of Aβ might require other, synergistic cytokines. Only one previous study has investigated this idea, but the authors used immortalized astrocytes and high/non-physiological concentrations of Aβ (Rossi and Bianchini, 1996). Here, we show that primary human astrocytes can be converted to a reactive, A1-like state using either the originally reported TNF-α + IL-1α + C1q cocktail, or substituted cocktails in which 10 nM Aβ replaces C1q or IL-1α.
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