Regular ArticleMyelination Following Transplantation of EGF-Responsive Neural Stem Cells into a Myelin-Deficient Environment☆
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Minocycline promotes remyelination in aggregating rat brain cell cultures after interferon-γ plus lipopolysaccharide-induced demyelination
2011, NeuroscienceCitation Excerpt :The increase in NG2 positive OPCs and O4 positive immature oligodendrocytes concomitant with the decrease in the number of nestin positive stem cells, suggests a shift towards oligodendrocyte maturation. This conclusion is in accordance with the observation that in response to demyelination, stem cells differentiate into NG2 positive cells and mature oligodendrocytes (Hammang et al., 1997). Moreover, it has been recently proposed that in MS lesions, endogenous neural stem cells contribute to the pool of remyelinating OPCs (Snethen et al., 2008).
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H. KettenmannB. R. Ransom, Eds.
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Present address: Department of Pediatrics, Emory University, Atlanta, GA.
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